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STRINGSTRING
ITSN1 ITSN1 ITSN2 ITSN2 LONP2 LONP2 UBOX5 UBOX5 FCHSD2 FCHSD2 SPG20 SPG20 KIR3DL1 KIR3DL1 TRIM45 TRIM45 STAC STAC KIR2DL1 KIR2DL1 SORBS1 SORBS1
"FCHSD2" - FCH and double SH3 domains 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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FCHSD2FCH and double SH3 domains 2; F-BAR domain containing (740 aa)    
Predicted Functional Partners:
ITSN1
Intersectin-1; Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1; C2 domain co [...] (1721 aa)
        
 
0.969
TRIM45
Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway; Ring finger proteins (580 aa)
            
  0.891
ITSN2
Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes; C2 domain containing (1697 aa)
        
 
0.844
STAC
SH3 and cysteine-rich domain-containing protein; Probably involved in a neuron-specific signal transduction (402 aa)
      
   
  0.840
SPG20
Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (666 aa)
            
  0.802
SORBS1
Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity) (1292 aa)
            
  0.796
KIR3DL1
Killer cell immunoglobulin-like receptor 3DL1; Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules (444 aa)
            
  0.733
KIR2DL1
Killer cell immunoglobulin-like receptor 2DL1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules (348 aa)
            
  0.701
UBOX5
RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates; Ring finger proteins (541 aa)
      
   
  0.696
LONP2
Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1; AAA ATPases (852 aa)
      
   
  0.674
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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