| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARPIN | C19orf24 | ENSP00000350075 | ENSP00000386557 | Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence; Belongs to the Arpin family | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | 0.559 |
| ATP5D | C19orf24 | ENSP00000215375 | ENSP00000386557 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | 0.685 |
| ATP5D | MIDN | ENSP00000215375 | ENSP00000300952 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion | 0.428 |
| C19orf24 | ARPIN | ENSP00000386557 | ENSP00000350075 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence; Belongs to the Arpin family | 0.559 |
| C19orf24 | ATP5D | ENSP00000386557 | ENSP00000215375 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] | 0.685 |
| C19orf24 | C19orf25 | ENSP00000386557 | ENSP00000397394 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | 0.652 |
| C19orf24 | C19orf26 | ENSP00000386557 | ENSP00000465260 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis | 0.584 |
| C19orf24 | C2CD4C | ENSP00000386557 | ENSP00000328677 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | 0.510 |
| C19orf24 | EMC7 | ENSP00000386557 | ENSP00000256545 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | ER membrane protein complex subunit 7 | 0.743 |
| C19orf24 | MIDN | ENSP00000386557 | ENSP00000300952 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion | 0.669 |
| C19orf24 | ODF3L2 | ENSP00000386557 | ENSP00000318029 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | Outer dense fiber of sperm tails 3 like 2 | 0.541 |
| C19orf24 | R3HDM4 | ENSP00000386557 | ENSP00000355385 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | R3H domain containing 4 | 0.634 |
| C19orf24 | SBNO2 | ENSP00000386557 | ENSP00000354733 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP- repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP- dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Pl [...] | 0.571 |
| C19orf25 | C19orf24 | ENSP00000397394 | ENSP00000386557 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | 0.652 |
| C19orf25 | C19orf26 | ENSP00000397394 | ENSP00000465260 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis | 0.429 |
| C19orf25 | MIDN | ENSP00000397394 | ENSP00000300952 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion | 0.510 |
| C19orf25 | SBNO2 | ENSP00000397394 | ENSP00000354733 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP- repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP- dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages. Pl [...] | 0.418 |
| C19orf26 | C19orf24 | ENSP00000465260 | ENSP00000386557 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 | 0.584 |
| C19orf26 | C19orf25 | ENSP00000465260 | ENSP00000397394 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family | 0.429 |
| C19orf26 | MIDN | ENSP00000465260 | ENSP00000300952 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion | 0.473 |
