node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DES | NEFM | ENSP00000363071 | ENSP00000221166 | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | 0.829 |
DES | SYNC | ENSP00000363071 | ENSP00000386439 | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.718 |
DES | SYNM | ENSP00000363071 | ENSP00000336775 | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] | Synemin; Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells; A-kinase anchoring proteins | 0.460 |
DES | VIM | ENSP00000363071 | ENSP00000446007 | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally | 0.987 |
DTNA | SSPN | ENSP00000470152 | ENSP00000242729 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily | Sarcospan; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC | 0.517 |
DTNA | SYNC | ENSP00000470152 | ENSP00000386439 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.899 |
DTNA | SYNM | ENSP00000470152 | ENSP00000336775 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. Dystrobrevin subfamily | Synemin; Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells; A-kinase anchoring proteins | 0.724 |
DTNB | SSPN | ENSP00000384084 | ENSP00000242729 | Dystrobrevin beta; Zinc fingers ZZ-type; Belongs to the dystrophin family. Dystrobrevin subfamily | Sarcospan; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC | 0.536 |
DTNB | SYNC | ENSP00000384084 | ENSP00000386439 | Dystrobrevin beta; Zinc fingers ZZ-type; Belongs to the dystrophin family. Dystrobrevin subfamily | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.710 |
ITGB1BP2 | SYNC | ENSP00000362935 | ENSP00000386439 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.668 |
NEFL | NEFM | ENSP00000482169 | ENSP00000221166 | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | 0.968 |
NEFL | SYNC | ENSP00000482169 | ENSP00000386439 | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.708 |
NEFL | VIM | ENSP00000482169 | ENSP00000446007 | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally | 0.694 |
NEFM | DES | ENSP00000221166 | ENSP00000363071 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-ancho [...] | 0.829 |
NEFM | NEFL | ENSP00000221166 | ENSP00000482169 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | 0.968 |
NEFM | NES | ENSP00000221166 | ENSP00000357206 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | 0.864 |
NEFM | SYNC | ENSP00000221166 | ENSP00000386439 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.667 |
NEFM | VIM | ENSP00000221166 | ENSP00000446007 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally | 0.830 |
NES | NEFM | ENSP00000357206 | ENSP00000221166 | Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber | 0.864 |
NES | SYNC | ENSP00000357206 | ENSP00000386439 | Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins | 0.706 |