• Version:
  • 11.0 [archived version]
STRINGSTRING
SF3A3 SF3A3 ANKRD49 ANKRD49 ANKRD46 ANKRD46 PHACTR2 PHACTR2 ANKRD30BL ANKRD30BL TRIM48 TRIM48 FOXI1 FOXI1 MESP1 MESP1 SLC6A16 SLC6A16 GABPB1 GABPB1 MESP2 MESP2
"ANKRD30BL" - Putative ankyrin repeat domain-containing protein 30B-like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANKRD30BLPutative ankyrin repeat domain-containing protein 30B-like; Ankyrin repeat domain containing (258 aa)    
Predicted Functional Partners:
MESP1
Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity); Basic helix-loop-helix proteins (268 aa)
       
 
  0.556
TRIM48
Tripartite motif containing 48; Belongs to the TRIM/RBCC family (224 aa)
     
 
  0.541
SLC6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5; Solute carrier family 6 member 16 (736 aa)
     
 
  0.493
FOXI1
Forkhead box protein I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity); Forkhead boxes (378 aa)
       
 
  0.465
SF3A3
Splicing factor 3A subunit 3; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex; U2 small nucleolar ribonucleoprotein (501 aa)
     
 
  0.459
MESP2
Mesoderm posterior protein 2; Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together w [...] (397 aa)
       
 
  0.448
PHACTR2
Phosphatase and actin regulator 2 (645 aa)
       
 
  0.446
ANKRD46
Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing (232 aa)
   
 
      0.443
ANKRD49
Ankyrin repeat domain-containing protein 49; Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF- kappaB pathway (By similarity); Ankyrin repeat domain containing (239 aa)
   
     
  0.436
GABPB1
GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Ankyrin repeat domain containing (395 aa)
   
        0.436
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]