| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COPS2 | NIF3L1 | ENSP00000299259 | ENSP00000386394 | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kina [...] | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.824 |
| MLXIPL | MXD4 | ENSP00000320886 | ENSP00000337889 | Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5’-CACGTG-3’ (By similarity); Basic helix-loop-helix proteins | Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins | 0.812 |
| MLXIPL | NIF3L1 | ENSP00000320886 | ENSP00000386394 | Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5’-CACGTG-3’ (By similarity); Basic helix-loop-helix proteins | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.812 |
| MXD4 | MLXIPL | ENSP00000337889 | ENSP00000320886 | Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins | Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5’-CACGTG-3’ (By similarity); Basic helix-loop-helix proteins | 0.812 |
| MXD4 | NIF3L1 | ENSP00000337889 | ENSP00000386394 | Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.755 |
| NIF3L1 | COPS2 | ENSP00000386394 | ENSP00000299259 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kina [...] | 0.824 |
| NIF3L1 | MLXIPL | ENSP00000386394 | ENSP00000320886 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5’-CACGTG-3’ (By similarity); Basic helix-loop-helix proteins | 0.812 |
| NIF3L1 | MXD4 | ENSP00000386394 | ENSP00000337889 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity); Basic helix-loop-helix proteins | 0.755 |
| NIF3L1 | PLXNB2 | ENSP00000386394 | ENSP00000409171 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | 0.834 |
| NIF3L1 | TACC1 | ENSP00000386394 | ENSP00000321703 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues | 0.807 |
| NIF3L1 | THOC7 | ENSP00000386394 | ENSP00000295899 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm vi [...] | 0.946 |
| NIF3L1 | TSG101 | ENSP00000386394 | ENSP00000251968 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding [...] | 0.861 |
| NIF3L1 | UNC50 | ENSP00000386394 | ENSP00000350409 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity) | 0.761 |
| NIF3L1 | VPS28 | ENSP00000386394 | ENSP00000366565 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process | 0.917 |
| NIF3L1 | VPS37B | ENSP00000386394 | ENSP00000267202 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | Vacuolar protein sorting-associated protein 37B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | 0.832 |
| PLXNB2 | NIF3L1 | ENSP00000409171 | ENSP00000386394 | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.834 |
| PLXNB2 | TACC1 | ENSP00000409171 | ENSP00000321703 | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues | 0.945 |
| TACC1 | NIF3L1 | ENSP00000321703 | ENSP00000386394 | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.807 |
| TACC1 | PLXNB2 | ENSP00000321703 | ENSP00000409171 | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at ’Tyr-1248’. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrati [...] | 0.945 |
| THOC7 | NIF3L1 | ENSP00000295899 | ENSP00000386394 | THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm vi [...] | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation | 0.946 |
