SAPCD2 protein (human) - STRING database

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SAPCD2

Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth (394 aa)

Predicted Functional Partners:

ARHGEF39

0.571

CDC20

0.541

CKAP2L

0.524

PLIN5

0.520

CCDC90B

0.516

BTBD3

0.510

PRR11

0.496

B4GALNT3

0.476

G2E3

0.461

LRRC17

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF39	BTBD3	ENSP00000367638	ENSP00000384545	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	0.580
ARHGEF39	CCDC90B	ENSP00000367638	ENSP00000434724	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	0.586
ARHGEF39	CDC20	ENSP00000367638	ENSP00000361540	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1- in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...]	0.541
ARHGEF39	CKAP2L	ENSP00000367638	ENSP00000305204	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells	0.703
ARHGEF39	G2E3	ENSP00000367638	ENSP00000206595	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death; PHD finger proteins	0.641
ARHGEF39	LRRC17	ENSP00000367638	ENSP00000344242	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity)	0.667
ARHGEF39	PRR11	ENSP00000367638	ENSP00000262293	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Proline-rich protein 11; Plays a critical role in cell cycle progression	0.608
ARHGEF39	SAPCD2	ENSP00000367638	ENSP00000386348	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth	0.571
B4GALNT3	SAPCD2	ENSP00000266383	ENSP00000386348	Beta-1,4-N-acetylgalactosaminyltransferase 3; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N’-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. Mediates the N,N’- diacetyllactosediamine formation on gastric mucosa; Belongs to the chondroitin N- acetylgalactosaminyltransferase family	Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth	0.476
BTBD3	ARHGEF39	ENSP00000384545	ENSP00000367638	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	0.580
BTBD3	CCDC90B	ENSP00000384545	ENSP00000434724	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	0.579
BTBD3	CKAP2L	ENSP00000384545	ENSP00000305204	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells	0.568
BTBD3	G2E3	ENSP00000384545	ENSP00000206595	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death; PHD finger proteins	0.559
BTBD3	LRRC17	ENSP00000384545	ENSP00000344242	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity)	0.550
BTBD3	PRR11	ENSP00000384545	ENSP00000262293	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Proline-rich protein 11; Plays a critical role in cell cycle progression	0.526
BTBD3	SAPCD2	ENSP00000384545	ENSP00000386348	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2. Involved also in positive regulation of cell proliferation and tumor cell growth	0.510
CCDC90B	ARHGEF39	ENSP00000434724	ENSP00000367638	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	Rho guanine nucleotide exchange factor 39; Promotes cell proliferation	0.586
CCDC90B	BTBD3	ENSP00000434724	ENSP00000384545	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed (By similarity); BTB domain containing	0.579
CCDC90B	CKAP2L	ENSP00000434724	ENSP00000305204	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells	0.541
CCDC90B	G2E3	ENSP00000434724	ENSP00000206595	Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B	G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death; PHD finger proteins	0.548

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