| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABHD1 | APOL6 | ENSP00000326491 | ENSP00000386280 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.500 |
| ABHD1 | ENDOD1 | ENSP00000326491 | ENSP00000278505 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | 0.658 |
| APOL6 | ABHD1 | ENSP00000386280 | ENSP00000326491 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.500 |
| APOL6 | ARHGAP39 | ENSP00000386280 | ENSP00000366522 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Rho GTPase activating protein 39 | 0.474 |
| APOL6 | BCL2L1 | ENSP00000386280 | ENSP00000302564 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | 0.492 |
| APOL6 | CD164 | ENSP00000386280 | ENSP00000309376 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Sialomucin core protein 24; Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity) | 0.474 |
| APOL6 | COMT | ENSP00000386280 | ENSP00000354511 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | 0.751 |
| APOL6 | ENDOD1 | ENSP00000386280 | ENSP00000278505 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | 0.511 |
| APOL6 | RGS13 | ENSP00000386280 | ENSP00000442837 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Regulator of G-protein signaling 13; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha (By similarity); Regulators of G-protein signaling | 0.552 |
| APOL6 | SP1 | ENSP00000386280 | ENSP00000329357 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | 0.643 |
| APOL6 | VAMP8 | ENSP00000386280 | ENSP00000263864 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] | 0.518 |
| APOL6 | WDR81 | ENSP00000386280 | ENSP00000386609 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic [...] | 0.599 |
| ARHGAP39 | APOL6 | ENSP00000366522 | ENSP00000386280 | Rho GTPase activating protein 39 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.474 |
| BCL2L1 | APOL6 | ENSP00000302564 | ENSP00000386280 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis; Belongs to the Bcl-2 family | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.492 |
| CD164 | APOL6 | ENSP00000309376 | ENSP00000386280 | Sialomucin core protein 24; Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity) | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.474 |
| COMT | APOL6 | ENSP00000354511 | ENSP00000386280 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Seven-beta-strand methyltransferase motif containing | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.751 |
| ENDOD1 | ABHD1 | ENSP00000278505 | ENSP00000326491 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family | 0.658 |
| ENDOD1 | APOL6 | ENSP00000278505 | ENSP00000386280 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.511 |
| RGS13 | APOL6 | ENSP00000442837 | ENSP00000386280 | Regulator of G-protein signaling 13; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha (By similarity); Regulators of G-protein signaling | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.552 |
| SP1 | APOL6 | ENSP00000329357 | ENSP00000386280 | Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...] | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins | 0.643 |
