node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | DDX27 | ENSP00000338862 | ENSP00000483495 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | 0.918 |
BRIX1 | EBNA1BP2 | ENSP00000338862 | ENSP00000407323 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family | 0.998 |
BRIX1 | FTSJ3 | ENSP00000338862 | ENSP00000396673 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | 0.985 |
BRIX1 | NIFK | ENSP00000338862 | ENSP00000285814 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing | 0.998 |
BRIX1 | NOP2 | ENSP00000338862 | ENSP00000371858 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family | 0.994 |
BRIX1 | NOP58 | ENSP00000338862 | ENSP00000264279 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.991 |
BRIX1 | PWP1 | ENSP00000338862 | ENSP00000387365 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Periodic tryptophan protein 1 homolog; May play an important role in cell growth and/or transcription; Belongs to the WD repeat PWP1 family | 0.930 |
BRIX1 | RBM28 | ENSP00000338862 | ENSP00000223073 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes; RNA binding motif containing | 0.939 |
BRIX1 | RBM34 | ENSP00000338862 | ENSP00000386226 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | RNA-binding protein 34; RNA binding motif containing; Belongs to the RRM RBM34 family | 0.986 |
BRIX1 | RPF2 | ENSP00000338862 | ENSP00000402338 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus | 0.989 |
DDX27 | BRIX1 | ENSP00000483495 | ENSP00000338862 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit | 0.918 |
DDX27 | EBNA1BP2 | ENSP00000483495 | ENSP00000407323 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family | 0.908 |
DDX27 | FTSJ3 | ENSP00000483495 | ENSP00000396673 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily | 0.985 |
DDX27 | NIFK | ENSP00000483495 | ENSP00000285814 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing | 0.993 |
DDX27 | NOP2 | ENSP00000483495 | ENSP00000371858 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family | 0.969 |
DDX27 | NOP58 | ENSP00000483495 | ENSP00000264279 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs; Belongs to the NOP5/NOP56 family | 0.978 |
DDX27 | PWP1 | ENSP00000483495 | ENSP00000387365 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Periodic tryptophan protein 1 homolog; May play an important role in cell growth and/or transcription; Belongs to the WD repeat PWP1 family | 0.889 |
DDX27 | RBM28 | ENSP00000483495 | ENSP00000223073 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes; RNA binding motif containing | 0.938 |
DDX27 | RBM34 | ENSP00000483495 | ENSP00000386226 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | RNA-binding protein 34; RNA binding motif containing; Belongs to the RRM RBM34 family | 0.981 |
DDX27 | RPF2 | ENSP00000483495 | ENSP00000402338 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3’ end formation of ribosomal 47S rRNA; DEAD-box helicases | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus | 0.923 |