node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGR3 | BZW2 | ENSP00000308606 | ENSP00000397249 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation | 0.782 |
AGR3 | ZNF12 | ENSP00000308606 | ENSP00000385939 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.473 |
BZW2 | AGR3 | ENSP00000397249 | ENSP00000308606 | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | 0.782 |
BZW2 | ZNF12 | ENSP00000397249 | ENSP00000385939 | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.521 |
DAGLB | ZNF12 | ENSP00000297056 | ENSP00000385939 | Sn1-specific diacylglycerol lipase beta; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses; Belongs to the AB hydrolase superfamily. Lipase family | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.491 |
DLC1 | GPM6B | ENSP00000276297 | ENSP00000316861 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B | 0.626 |
DLC1 | SYN3 | ENSP00000276297 | ENSP00000351614 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | 0.538 |
DLC1 | ZNF12 | ENSP00000276297 | ENSP00000385939 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.534 |
FBXL14 | ZNF12 | ENSP00000344855 | ENSP00000385939 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1; F-box and leucine rich repeat proteins | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.511 |
GPM6B | DLC1 | ENSP00000316861 | ENSP00000276297 | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality | 0.626 |
GPM6B | SYN3 | ENSP00000316861 | ENSP00000351614 | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | 0.596 |
GPM6B | ZNF12 | ENSP00000316861 | ENSP00000385939 | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.536 |
LSM14B | ZNF12 | ENSP00000279068 | ENSP00000385939 | Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.575 |
MSANTD3 | ZNF12 | ENSP00000480445 | ENSP00000385939 | Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.447 |
SYN3 | DLC1 | ENSP00000351614 | ENSP00000276297 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality | 0.538 |
SYN3 | GPM6B | ENSP00000351614 | ENSP00000316861 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B | 0.596 |
SYN3 | ZNF12 | ENSP00000351614 | ENSP00000385939 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.466 |
TRIM28 | ZNF12 | ENSP00000253024 | ENSP00000385939 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.903 |
ZNF12 | AGR3 | ENSP00000385939 | ENSP00000308606 | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | 0.473 |
ZNF12 | BZW2 | ENSP00000385939 | ENSP00000397249 | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation | 0.521 |