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  • 11.0 [archived version]
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SYN3 SYN3 MSANTD3 MSANTD3 DLC1 DLC1 GPM6B GPM6B DAGLB DAGLB ZNF12 ZNF12 BZW2 BZW2 AGR3 AGR3 FBXL14 FBXL14 TRIM28 TRIM28 LSM14B LSM14B
"ZNF12" - Zinc finger protein 12 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ZNF12Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-type zinc-finger protein family (697 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
LSM14B
Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins (385 aa)
     
   
  0.575
GPM6B
cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B (328 aa)
           
  0.536
DLC1
Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (1528 aa)
           
  0.534
BZW2
Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation (419 aa)
       
 
  0.521
FBXL14
F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1; F-box and leucine rich repeat proteins (418 aa)
     
 
  0.511
DAGLB
Sn1-specific diacylglycerol lipase beta; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses; Belongs to the AB hydrolase superfamily. Lipase family (672 aa)
           
  0.491
AGR3
Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family (166 aa)
           
  0.473
SYN3
Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins (580 aa)
           
  0.466
MSANTD3
Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family (275 aa)
           
  0.447
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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