| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMER3 | FAM168B | ENSP00000392700 | ENSP00000387051 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.589 |
| AMER3 | PLEKHB2 | ENSP00000392700 | ENSP00000385892 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.543 |
| ASB1 | PLEKHB2 | ENSP00000264607 | ENSP00000385892 | Ankyrin repeat and SOCS box protein 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.606 |
| ASB1 | UBB | ENSP00000264607 | ENSP00000304697 | Ankyrin repeat and SOCS box protein 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | Polyubiquitin-B; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.916 |
| ATP8A1 | FAM168B | ENSP00000371084 | ENSP00000387051 | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.514 |
| ATP8A1 | PLEKHB2 | ENSP00000371084 | ENSP00000385892 | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.510 |
| CELF4 | PLEKHB2 | ENSP00000410584 | ENSP00000385892 | CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic site [...] | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.607 |
| DHX35 | PLEKHB2 | ENSP00000252011 | ENSP00000385892 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.503 |
| FAM168B | AMER3 | ENSP00000387051 | ENSP00000392700 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | 0.589 |
| FAM168B | ATP8A1 | ENSP00000387051 | ENSP00000371084 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | 0.514 |
| FAM168B | PLEKHB2 | ENSP00000387051 | ENSP00000385892 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | 0.531 |
| PLEKHB2 | AMER3 | ENSP00000385892 | ENSP00000392700 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) | 0.543 |
| PLEKHB2 | ASB1 | ENSP00000385892 | ENSP00000264607 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Ankyrin repeat and SOCS box protein 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family | 0.606 |
| PLEKHB2 | ATP8A1 | ENSP00000385892 | ENSP00000371084 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | 0.510 |
| PLEKHB2 | CELF4 | ENSP00000385892 | ENSP00000410584 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic site [...] | 0.607 |
| PLEKHB2 | DHX35 | ENSP00000385892 | ENSP00000252011 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily | 0.503 |
| PLEKHB2 | FAM168B | ENSP00000385892 | ENSP00000387051 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) | 0.531 |
| PLEKHB2 | PLEKHG1 | ENSP00000385892 | ENSP00000356297 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Pleckstrin homology and RhoGEF domain containing G1 | 0.531 |
| PLEKHB2 | PLEKHH3 | ENSP00000385892 | ENSP00000468678 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Pleckstrin homology, MyTH4 and FERM domain containing H3 | 0.563 |
| PLEKHB2 | TMEM87B | ENSP00000385892 | ENSP00000283206 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing | Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN); Belongs to the LU7TM family. TMEM87 subfamily | 0.497 |
