node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASAP2 | FAM124B | ENSP00000281419 | ENSP00000386895 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | 0.643 |
ASAP2 | ICA1 | ENSP00000281419 | ENSP00000385570 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | 0.621 |
ASAP2 | PKP2 | ENSP00000281419 | ENSP00000070846 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | 0.557 |
ASAP2 | TPRG1 | ENSP00000281419 | ENSP00000341031 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | Tumor protein p63 regulated 1; Belongs to the TPRG1 family | 0.642 |
FAM124B | ASAP2 | ENSP00000386895 | ENSP00000281419 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | 0.643 |
FAM124B | ICA1 | ENSP00000386895 | ENSP00000385570 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | 0.642 |
FAM124B | PKP2 | ENSP00000386895 | ENSP00000070846 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | 0.548 |
FAM124B | TPRG1 | ENSP00000386895 | ENSP00000341031 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | Tumor protein p63 regulated 1; Belongs to the TPRG1 family | 0.679 |
ICA1 | ASAP2 | ENSP00000385570 | ENSP00000281419 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | 0.621 |
ICA1 | FAM124B | ENSP00000385570 | ENSP00000386895 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family | 0.642 |
ICA1 | PICK1 | ENSP00000385570 | ENSP00000385205 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] | 0.859 |
ICA1 | PKP2 | ENSP00000385570 | ENSP00000070846 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | 0.636 |
ICA1 | PTPRN | ENSP00000385570 | ENSP00000295718 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation [...] | 0.623 |
ICA1 | RAB2A | ENSP00000385570 | ENSP00000262646 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases | 0.715 |
ICA1 | RNF144B | ENSP00000385570 | ENSP00000259939 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se | 0.670 |
ICA1 | SGSM1 | ENSP00000385570 | ENSP00000383212 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family | 0.645 |
ICA1 | SLC25A13 | ENSP00000385570 | ENSP00000400101 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Calcium-binding mitochondrial carrier protein Aralar2; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle; EF-hand domain containing | 0.581 |
ICA1 | TPRG1 | ENSP00000385570 | ENSP00000341031 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Tumor protein p63 regulated 1; Belongs to the TPRG1 family | 0.714 |
PICK1 | ICA1 | ENSP00000385205 | ENSP00000385570 | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | 0.859 |
PKP2 | ASAP2 | ENSP00000070846 | ENSP00000281419 | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration; Ankyrin repeat domain containing | 0.557 |