ALS2CR12 protein (human) - STRING database

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ALS2CR12

Amyotrophic lateral sclerosis 2 chromosome region 12 (445 aa)

Predicted Functional Partners:

SULT2B1

0.782

ALS2CR11

0.646

TRAK2

0.587

C2orf74

0.524

FAM126B

0.495

NIF3L1

0.493

RBM26

0.454

ENSG00000269881

0.450

ITFG3

0.443

CASP8

0.428

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALS2CR11	ALS2CR12	ENSP00000409937	ENSP00000385098	C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	Amyotrophic lateral sclerosis 2 chromosome region 12	0.646
ALS2CR11	FAM126B	ENSP00000409937	ENSP00000393667	C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family	0.516
ALS2CR11	NIF3L1	ENSP00000409937	ENSP00000386394	C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation	0.515
ALS2CR12	ALS2CR11	ENSP00000385098	ENSP00000409937	Amyotrophic lateral sclerosis 2 chromosome region 12	C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	0.646
ALS2CR12	C2orf74	ENSP00000385098	ENSP00000402915	Amyotrophic lateral sclerosis 2 chromosome region 12	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74	0.524
ALS2CR12	CASP8	ENSP00000385098	ENSP00000351273	Amyotrophic lateral sclerosis 2 chromosome region 12	Caspase-8; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, [...]	0.428
ALS2CR12	ENSG00000269881	ENSP00000385098	ENSP00000471331	Amyotrophic lateral sclerosis 2 chromosome region 12	cDNA FLJ60496; Protein ITFG3; Uncharacterized protein; cDNA FLJ60496	0.450
ALS2CR12	FAM126B	ENSP00000385098	ENSP00000393667	Amyotrophic lateral sclerosis 2 chromosome region 12	Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family	0.495
ALS2CR12	ITFG3	ENSP00000385098	ENSP00000382814	Amyotrophic lateral sclerosis 2 chromosome region 12	Protein FAM234A; Integrin alpha FG-GAP repeat containing 3; Belongs to the FAM234 family	0.443
ALS2CR12	NIF3L1	ENSP00000385098	ENSP00000386394	Amyotrophic lateral sclerosis 2 chromosome region 12	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation	0.493
ALS2CR12	RBM26	ENSP00000385098	ENSP00000483408	Amyotrophic lateral sclerosis 2 chromosome region 12	RNA-binding protein 26; Protein phosphatase 1 regulatory subunits	0.454
ALS2CR12	SULT2B1	ENSP00000385098	ENSP00000201586	Amyotrophic lateral sclerosis 2 chromosome region 12	Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal choleste [...]	0.782
ALS2CR12	TRAK2	ENSP00000385098	ENSP00000328875	Amyotrophic lateral sclerosis 2 chromosome region 12	Trafficking kinesin-binding protein 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR	0.587
C2orf74	ALS2CR12	ENSP00000402915	ENSP00000385098	Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74	Amyotrophic lateral sclerosis 2 chromosome region 12	0.524
CASP8	ALS2CR12	ENSP00000351273	ENSP00000385098	Caspase-8; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, [...]	Amyotrophic lateral sclerosis 2 chromosome region 12	0.428
ENSG00000269881	ALS2CR12	ENSP00000471331	ENSP00000385098	cDNA FLJ60496; Protein ITFG3; Uncharacterized protein; cDNA FLJ60496	Amyotrophic lateral sclerosis 2 chromosome region 12	0.450
FAM126B	ALS2CR11	ENSP00000393667	ENSP00000409937	Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family	C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	0.516
FAM126B	ALS2CR12	ENSP00000393667	ENSP00000385098	Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family	Amyotrophic lateral sclerosis 2 chromosome region 12	0.495
FAM126B	NIF3L1	ENSP00000393667	ENSP00000386394	Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family	NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation	0.730
ITFG3	ALS2CR12	ENSP00000382814	ENSP00000385098	Protein FAM234A; Integrin alpha FG-GAP repeat containing 3; Belongs to the FAM234 family	Amyotrophic lateral sclerosis 2 chromosome region 12	0.443

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