node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACN9 | NUBPL | ENSP00000414066 | ENSP00000281081 | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits; Belongs to the Mrp/NBP35 ATP-binding proteins family | 0.704 |
ACN9 | SLC22A23 | ENSP00000414066 | ENSP00000385028 | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1 | Solute carrier family 22 member 23 | 0.687 |
DNAJC15 | SLC22A23 | ENSP00000368523 | ENSP00000385028 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9; DNAJ heat shock proteins | Solute carrier family 22 member 23 | 0.719 |
ERICH1 | PCIF1 | ENSP00000262109 | ENSP00000361486 | Glutamate-rich protein 1; Glutamate rich 1 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | 0.684 |
ERICH1 | PXDC1 | ENSP00000262109 | ENSP00000369636 | Glutamate-rich protein 1; Glutamate rich 1 | PX domain containing 1 | 0.698 |
ERICH1 | RSBN1L | ENSP00000262109 | ENSP00000334040 | Glutamate-rich protein 1; Glutamate rich 1 | Round spermatid basic protein 1 like | 0.632 |
ERICH1 | SLC22A23 | ENSP00000262109 | ENSP00000385028 | Glutamate-rich protein 1; Glutamate rich 1 | Solute carrier family 22 member 23 | 0.657 |
FUCA2 | SLC22A23 | ENSP00000002165 | ENSP00000385028 | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family | Solute carrier family 22 member 23 | 0.682 |
NUBPL | ACN9 | ENSP00000281081 | ENSP00000414066 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits; Belongs to the Mrp/NBP35 ATP-binding proteins family | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1 | 0.704 |
NUBPL | SLC22A23 | ENSP00000281081 | ENSP00000385028 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits; Belongs to the Mrp/NBP35 ATP-binding proteins family | Solute carrier family 22 member 23 | 0.746 |
PCIF1 | ERICH1 | ENSP00000361486 | ENSP00000262109 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | Glutamate-rich protein 1; Glutamate rich 1 | 0.684 |
PCIF1 | PXDC1 | ENSP00000361486 | ENSP00000369636 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | PX domain containing 1 | 0.669 |
PCIF1 | RSBN1L | ENSP00000361486 | ENSP00000334040 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | Round spermatid basic protein 1 like | 0.626 |
PCIF1 | SLC22A23 | ENSP00000361486 | ENSP00000385028 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | Solute carrier family 22 member 23 | 0.633 |
PRPF4B | PXDC1 | ENSP00000337194 | ENSP00000369636 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | PX domain containing 1 | 0.794 |
PRPF4B | SLC22A23 | ENSP00000337194 | ENSP00000385028 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | Solute carrier family 22 member 23 | 0.721 |
PXDC1 | ERICH1 | ENSP00000369636 | ENSP00000262109 | PX domain containing 1 | Glutamate-rich protein 1; Glutamate rich 1 | 0.698 |
PXDC1 | PCIF1 | ENSP00000369636 | ENSP00000361486 | PX domain containing 1 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits | 0.669 |
PXDC1 | PRPF4B | ENSP00000369636 | ENSP00000337194 | PX domain containing 1 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF | 0.794 |
PXDC1 | RSBN1L | ENSP00000369636 | ENSP00000334040 | PX domain containing 1 | Round spermatid basic protein 1 like | 0.736 |