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  • 11.0 [archived version]
STRINGSTRING
MRPS2 MRPS2 GFER GFER HSPA4L HSPA4L THAP4 THAP4 THAP11 THAP11 DTYMK DTYMK ANKMY1 ANKMY1 C2orf54 C2orf54 PRKRIR PRKRIR STK25 STK25 ANO7 ANO7
"THAP4" - THAP domain containing 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
THAP4THAP domain containing 4 (577 aa)    
Predicted Functional Partners:
THAP11
THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing (314 aa)
      
   
  0.921
PRKRIR
52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth (761 aa)
            
  0.800
HSPA4L
Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family (839 aa)
            
  0.719
ANKMY1
Ankyrin repeat and MYND domain containing 1 (1030 aa)
            
  0.709
C2orf54
Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 (447 aa)
            
  0.707
GFER
FAD-linked sulfhydryl oxidase ALR; Isoform 1- FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen (205 aa)
      
      0.676
STK25
Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (426 aa)
      
   
  0.665
DTYMK
Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family (212 aa)
      
   
  0.664
MRPS2
Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family (296 aa)
      
        0.660
ANO7
Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions; Anoctamins (933 aa)
            
  0.643
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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