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STRINGSTRING
ZNF74 ZNF74 SGSM1 SGSM1 LIMK1 LIMK1 C22orf15 C22orf15 RGL4 RGL4 GUCD1 GUCD1 SPECC1L SPECC1L DRICH1 DRICH1 LRRC75B LRRC75B ZNF70 ZNF70 VPREB3 VPREB3
"C22orf15" - Uncharacterized protein C22orf15 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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C22orf15Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 (148 aa)    
Predicted Functional Partners:
LIMK1
LIM domain kinase 1; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin- 2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. I [...] (647 aa)
        
      0.798
LRRC75B
Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B (315 aa)
            
  0.703
GUCD1
Protein GUCD1; Guanylyl cyclase domain containing 1 (296 aa)
            
  0.670
DRICH1
Aspartate-rich protein 1; Aspartate rich 1 (229 aa)
            
  0.655
ZNF70
Zinc finger protein 70; May be involved in transcriptional regulation; Zinc fingers C2H2-type (446 aa)
            
  0.645
RGL4
Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 (473 aa)
            
  0.584
SPECC1L
Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration; Belongs to the cytospin-A family (1117 aa)
            
  0.530
SGSM1
Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family (1148 aa)
            
  0.514
ZNF74
Zinc finger protein 74; May play a role in RNA metabolism; Belongs to the krueppel C2H2-type zinc-finger protein family (644 aa)
            
  0.513
VPREB3
Pre-B lymphocyte protein 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells; V-set domain containing (123 aa)
      
   
  0.492
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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