• Version:
  • 11.0 [archived version]
STRINGSTRING
GCC2 GCC2 KIF12 KIF12 VWF VWF SVEP1 SVEP1 HDHD3 HDHD3 SFXN1 SFXN1 SFXN3 SFXN3 SNRNP200 SNRNP200 HSPA14 HSPA14 SFXN5 SFXN5 SFXN2 SFXN2
"SVEP1" - Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process; Sushi domain containing (3574 aa)    
Predicted Functional Partners:
GCC2
GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa)
           
  0.678
SNRNP200
U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome (2136 aa)
     
   
  0.670
SFXN2
Sideroflexin-2; Potential iron transporter; Sideroflexins (322 aa)
           
  0.626
SFXN1
Sideroflexin-1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria; Sideroflexins (322 aa)
           
  0.626
SFXN3
Sideroflexin-3; Potential iron transporter; Sideroflexins (325 aa)
           
  0.626
SFXN5
Sideroflexin-5; Transports citrate. Potential iron transporter (By similarity); Sideroflexins (340 aa)
           
  0.623
HSPA14
Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity; Belongs to the heat shock protein 70 family (509 aa)
     
 
  0.610
VWF
Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma; Endogenous ligands (2813 aa)
     
 
  0.601
KIF12
Kinesin-like protein KIF12; Kinesin family member 12; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family (513 aa)
       
 
  0.589
HDHD3
Haloacid dehalogenase like hydrolase domain containing 3 (251 aa)
           
  0.582
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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