| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APIP | FAM104A | ENSP00000379133 | ENSP00000384832 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily | Protein FAM104A; Family with sequence similarity 104 member A | 0.540 |
| EEF1B2 | FAM104A | ENSP00000376056 | ENSP00000384832 | Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP | Protein FAM104A; Family with sequence similarity 104 member A | 0.445 |
| FAM104A | APIP | ENSP00000384832 | ENSP00000379133 | Protein FAM104A; Family with sequence similarity 104 member A | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily | 0.540 |
| FAM104A | EEF1B2 | ENSP00000384832 | ENSP00000376056 | Protein FAM104A; Family with sequence similarity 104 member A | Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP | 0.445 |
| FAM104A | IKZF4 | ENSP00000384832 | ENSP00000262032 | Protein FAM104A; Family with sequence similarity 104 member A | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | 0.471 |
| FAM104A | KCTD6 | ENSP00000384832 | ENSP00000347188 | Protein FAM104A; Family with sequence similarity 104 member A | BTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11-KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblasto [...] | 0.588 |
| FAM104A | LAMC3 | ENSP00000384832 | ENSP00000354360 | Protein FAM104A; Family with sequence similarity 104 member A | Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.695 |
| FAM104A | MOCS2 | ENSP00000384832 | ENSP00000380157 | Protein FAM104A; Family with sequence similarity 104 member A | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily | 0.478 |
| FAM104A | POLA2 | ENSP00000384832 | ENSP00000265465 | Protein FAM104A; Family with sequence similarity 104 member A | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery | 0.702 |
| FAM104A | UBXN2B | ENSP00000384832 | ENSP00000382507 | Protein FAM104A; Family with sequence similarity 104 member A | UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity; Belongs to the NSFL1C family | 0.822 |
| FAM104A | UBXN6 | ENSP00000384832 | ENSP00000301281 | Protein FAM104A; Family with sequence similarity 104 member A | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes; UBX domain containing | 0.847 |
| FAM104A | VCP | ENSP00000384832 | ENSP00000351777 | Protein FAM104A; Family with sequence similarity 104 member A | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.852 |
| IKZF4 | FAM104A | ENSP00000262032 | ENSP00000384832 | Zinc finger protein Eos; DNA-binding protein that binds to the 5’GGGAATRCC-3’ Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity) | Protein FAM104A; Family with sequence similarity 104 member A | 0.471 |
| KCTD6 | FAM104A | ENSP00000347188 | ENSP00000384832 | BTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11-KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblasto [...] | Protein FAM104A; Family with sequence similarity 104 member A | 0.588 |
| LAMC3 | FAM104A | ENSP00000354360 | ENSP00000384832 | Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | Protein FAM104A; Family with sequence similarity 104 member A | 0.695 |
| LAMC3 | POLA2 | ENSP00000354360 | ENSP00000265465 | Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery | 0.671 |
| MOCS2 | FAM104A | ENSP00000380157 | ENSP00000384832 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily | Protein FAM104A; Family with sequence similarity 104 member A | 0.478 |
| POLA2 | FAM104A | ENSP00000265465 | ENSP00000384832 | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery | Protein FAM104A; Family with sequence similarity 104 member A | 0.702 |
| POLA2 | LAMC3 | ENSP00000265465 | ENSP00000354360 | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery | Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.671 |
| UBXN2B | FAM104A | ENSP00000382507 | ENSP00000384832 | UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity; Belongs to the NSFL1C family | Protein FAM104A; Family with sequence similarity 104 member A | 0.822 |
