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  • 11.0 [archived version]
STRINGSTRING
MOS MOS ZBTB32 ZBTB32 FOXL2 FOXL2 BOLA2B BOLA2B WIZ WIZ ZGLP1 ZGLP1 GATA6 GATA6 BOLA2 BOLA2 PABPC1L PABPC1L LSM14B LSM14B EIF4E1B EIF4E1B
"ZGLP1" - GATA-type zinc finger protein 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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ZGLP1GATA-type zinc finger protein 1; Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription factor function (By similarity); GATA zinc finger domain containing (271 aa)    
Predicted Functional Partners:
GATA6
Transcription factor GATA-6; Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial cells from bacterial infection. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity); GATA zinc finger domain containing (595 aa)
           
  0.805
WIZ
Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity); Zinc fingers C2H2-type (794 aa)
       
 
  0.532
FOXL2
Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic [...] (376 aa)
       
 
  0.515
MOS
MOS proto-oncogene, serine/threonine kinase (346 aa)
       
 
  0.496
ZBTB32
Zinc finger and BTB domain-containing protein 32; DNA-binding protein that binds to the to a 5’- TGTACAGTGT-3’ core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity); BTB domain containing (487 aa)
       
 
  0.445
LSM14B
Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins (385 aa)
           
  0.442
PABPC1L
Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing (614 aa)
     
   
  0.428
EIF4E1B
Eukaryotic translation initiation factor 4E type 1B; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure (242 aa)
           
  0.426
BOLA2
BolA-like protein 2; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3; Belongs to the BolA/IbaG family (152 aa)
       
 
  0.422
BOLA2B
bolA family member 2B; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3; Belongs to the BolA/IbaG family (152 aa)
       
 
  0.422
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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