| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGO1 | DCP1A | ENSP00000362300 | ENSP00000476046 | Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs); Argonaute/PIWI family | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | 0.641 |
| AGO1 | MEX3D | ENSP00000362300 | ENSP00000384398 | Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs); Argonaute/PIWI family | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.701 |
| DCP1A | AGO1 | ENSP00000476046 | ENSP00000362300 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs); Argonaute/PIWI family | 0.641 |
| DCP1A | MEX3D | ENSP00000476046 | ENSP00000384398 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.662 |
| GCOM1 | MEX3D | ENSP00000465231 | ENSP00000384398 | GRINL1A combined protein 15; GRINL1A complex locus 1 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.585 |
| HNRNPK | MEX3D | ENSP00000365439 | ENSP00000384398 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.757 |
| MBD3 | MEX3D | ENSP00000412302 | ENSP00000384398 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.717 |
| MEX3D | AGO1 | ENSP00000384398 | ENSP00000362300 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs); Argonaute/PIWI family | 0.701 |
| MEX3D | DCP1A | ENSP00000384398 | ENSP00000476046 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5’- phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family | 0.662 |
| MEX3D | GCOM1 | ENSP00000384398 | ENSP00000465231 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | GRINL1A combined protein 15; GRINL1A complex locus 1 | 0.585 |
| MEX3D | HNRNPK | ENSP00000384398 | ENSP00000365439 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription [...] | 0.757 |
| MEX3D | MBD3 | ENSP00000384398 | ENSP00000412302 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | 0.717 |
| MEX3D | MSTO1 | ENSP00000384398 | ENSP00000245564 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Protein misato homolog 1; Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation; Belongs to the misato family | 0.635 |
| MEX3D | PAPD4 | ENSP00000384398 | ENSP00000397563 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.583 |
| MEX3D | ZSWIM2 | ENSP00000384398 | ENSP00000295131 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes; Ring finger proteins | 0.491 |
| MEX3D | ZYG11A | ENSP00000384398 | ENSP00000360583 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Protein zyg-11 homolog A; Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC; Armadillo-like helical domain containing | 0.514 |
| MEX3D | ZYG11B | ENSP00000384398 | ENSP00000294353 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | Protein zyg-11 homolog B; Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC; Armadillo-like helical domain containing | 0.563 |
| MSTO1 | MEX3D | ENSP00000245564 | ENSP00000384398 | Protein misato homolog 1; Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation; Belongs to the misato family | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.635 |
| PAPD4 | MEX3D | ENSP00000397563 | ENSP00000384398 | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.583 |
| ZSWIM2 | MEX3D | ENSP00000295131 | ENSP00000384398 | E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes; Ring finger proteins | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins | 0.491 |
