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  • 11.0 [archived version]
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IMMP2L IMMP2L FER1L6 FER1L6 IQCG IQCG MEIG1 MEIG1 SPATA4 SPATA4 MORN3 MORN3 SPAG16 SPAG16 PACRG PACRG RSPH1 RSPH1 SPAG6 SPAG6 TEKT2 TEKT2
"MEIG1" - Meiosis expressed gene 1 protein homolog in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MEIG1Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis (88 aa)    
Predicted Functional Partners:
SPAG16
Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing (631 aa)
       
 
  0.992
SPAG6
Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing (509 aa)
     
   
  0.935
PACRG
Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease; Armadillo-like helical domain containing (296 aa)
     
 
  0.825
IQCG
IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility (443 aa)
           
  0.712
SPATA4
Spermatogenesis-associated protein 4; Spermatogenesis associated 4 (305 aa)
     
   
  0.690
MORN3
MORN repeat containing 3 (240 aa)
     
   
  0.633
FER1L6
Fer-1-like protein 6; Fer-1 like family member 6 (1857 aa)
           
  0.584
TEKT2
Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Tektins (430 aa)
     
   
  0.531
RSPH1
Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes (309 aa)
     
   
  0.510
IMMP2L
Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily (175 aa)
           
  0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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