• Version:
  • 11.0 [archived version]
STRINGSTRING
CD40 CD40 OR5K3 OR5K3 LONRF2 LONRF2 CTNNA2 CTNNA2 PDZRN4 PDZRN4 TAF3 TAF3 PCED1B PCED1B TMEM154 TMEM154 STK32B STK32B SULT4A1 SULT4A1 CCDC184 CCDC184
"PDZRN4" - PDZ domain containing ring finger 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PDZRN4PDZ domain containing ring finger 4 (1036 aa)    
Predicted Functional Partners:
SULT4A1
Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS; Sulfotransferases, cytosolic (284 aa)
      
   
  0.726
OR5K3
Olfactory receptor 5K3; Odorant receptor; Olfactory receptors, family 5 (321 aa)
        
 
  0.646
TAF3
Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process; Armadillo-like helical domain containing (929 aa)
      
        0.636
LONRF2
LON peptidase N-terminal domain and ring finger 2 (754 aa)
      
 
  0.580
PCED1B
PC-esterase domain containing 1B; Belongs to the PC-esterase family (432 aa)
            
  0.580
CD40
Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (277 aa)
      
      0.561
CCDC184
Coiled-coil domain containing 184 (194 aa)
      
   
  0.561
CTNNA2
Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation; Alpha catenins (953 aa)
      
 
  0.554
STK32B
Serine/threonine kinase 32B (414 aa)
      
   
  0.547
TMEM154
Transmembrane protein 154 (183 aa)
            
  0.536
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >