node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C11orf30 | LRRC32 | ENSP00000433205 | ENSP00000384126 | BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.673 |
CTLA4 | FOXP3 | ENSP00000303939 | ENSP00000365380 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | Forkhead box protein P3; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of T [...] | 0.997 |
CTLA4 | LRRC32 | ENSP00000303939 | ENSP00000384126 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.526 |
DCBLD2 | ESAM | ENSP00000321573 | ENSP00000278927 | Discoidin, CUB and LCCL domain containing 2 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.745 |
DCBLD2 | LRRC32 | ENSP00000321573 | ENSP00000384126 | Discoidin, CUB and LCCL domain containing 2 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.766 |
ESAM | DCBLD2 | ENSP00000278927 | ENSP00000321573 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Discoidin, CUB and LCCL domain containing 2 | 0.745 |
ESAM | LRRC32 | ENSP00000278927 | ENSP00000384126 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.718 |
FOXP3 | CTLA4 | ENSP00000365380 | ENSP00000303939 | Forkhead box protein P3; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of T [...] | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | 0.997 |
FOXP3 | LRRC32 | ENSP00000365380 | ENSP00000384126 | Forkhead box protein P3; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of T [...] | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.646 |
LPHN1 | LRRC32 | ENSP00000340688 | ENSP00000384126 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.685 |
LPHN2 | LRRC32 | ENSP00000322270 | ENSP00000384126 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.685 |
LPHN3 | LRRC32 | ENSP00000422533 | ENSP00000384126 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | 0.685 |
LRRC32 | C11orf30 | ENSP00000384126 | ENSP00000433205 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors | 0.673 |
LRRC32 | CTLA4 | ENSP00000384126 | ENSP00000303939 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 | 0.526 |
LRRC32 | DCBLD2 | ENSP00000384126 | ENSP00000321573 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Discoidin, CUB and LCCL domain containing 2 | 0.766 |
LRRC32 | ESAM | ENSP00000384126 | ENSP00000278927 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily | 0.718 |
LRRC32 | FOXP3 | ENSP00000384126 | ENSP00000365380 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Forkhead box protein P3; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of T [...] | 0.646 |
LRRC32 | LPHN1 | ENSP00000384126 | ENSP00000340688 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
LRRC32 | LPHN2 | ENSP00000384126 | ENSP00000322270 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.685 |
LRRC32 | LPHN3 | ENSP00000384126 | ENSP00000422533 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.685 |