CCDC85A protein (human) - STRING database

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CCDC85A

Coiled-coil domain containing 85A; Belongs to the CCDC85 family (553 aa)

Predicted Functional Partners:

ARHGAP23

0.844

ARHGAP21

0.841

TMEM132C

0.620

OR4K14

0.609

C11orf80

0.600

CCDC184

0.597

ARVCF

0.580

OR4N5

0.577

SNX16

0.558

KLHL4

0.552

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP21	CCDC85A	ENSP00000379709	ENSP00000384040	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.841
ARHGAP23	CCDC85A	ENSP00000481862	ENSP00000384040	Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; PDZ domain containing	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.844
ARVCF	CCDC85A	ENSP00000263207	ENSP00000384040	Armadillo repeat protein deleted in velo-cardio-facial syndrome; Involved in protein-protein interactions at adherens junctions; Belongs to the beta-catenin family	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.580
C11orf80	CCDC85A	ENSP00000354227	ENSP00000384040	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.600
C11orf80	KLHL4	ENSP00000354227	ENSP00000362206	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.636
C11orf80	OR4K14	ENSP00000354227	ENSP00000305011	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.726
C11orf80	OR4N5	ENSP00000354227	ENSP00000332110	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.712
C11orf80	TMEM132C	ENSP00000354227	ENSP00000410852	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.683
CCDC184	CCDC85A	ENSP00000320849	ENSP00000384040	Coiled-coil domain containing 184	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	0.597
CCDC184	SNX16	ENSP00000320849	ENSP00000379621	Coiled-coil domain containing 184	Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family	0.502
CCDC85A	ARHGAP21	ENSP00000384040	ENSP00000379709	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions; PDZ domain containing	0.841
CCDC85A	ARHGAP23	ENSP00000384040	ENSP00000481862	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; PDZ domain containing	0.844
CCDC85A	ARVCF	ENSP00000384040	ENSP00000263207	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Armadillo repeat protein deleted in velo-cardio-facial syndrome; Involved in protein-protein interactions at adherens junctions; Belongs to the beta-catenin family	0.580
CCDC85A	C11orf80	ENSP00000384040	ENSP00000354227	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	0.600
CCDC85A	CCDC184	ENSP00000384040	ENSP00000320849	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Coiled-coil domain containing 184	0.597
CCDC85A	KLHL4	ENSP00000384040	ENSP00000362206	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Kelch-like protein 4; Kelch like family member 4; BTB domain containing	0.552
CCDC85A	OR4K14	ENSP00000384040	ENSP00000305011	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.609
CCDC85A	OR4N5	ENSP00000384040	ENSP00000332110	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.577
CCDC85A	SNX16	ENSP00000384040	ENSP00000379621	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm; Belongs to the sorting nexin family	0.558
CCDC85A	TMEM132C	ENSP00000384040	ENSP00000410852	Coiled-coil domain containing 85A; Belongs to the CCDC85 family	Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits	0.620

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