• Version:
  • 11.0 [archived version]
STRINGSTRING
CPA5 CPA5 MRPS33 MRPS33 ARNT2 ARNT2 USF1 USF1 CARF CARF CCDC173 CCDC173 BHLHE40 BHLHE40 C1orf27 C1orf27 FNDC1 FNDC1 CDC5L CDC5L XRN2 XRN2
"CARF" - Calcium-responsive transcription factor in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CARFCalcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence (725 aa)    
Predicted Functional Partners:
CDC5L
Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing (802 aa)
       
      0.980
CCDC173
Coiled-coil domain containing 173 (552 aa)
           
  0.775
C1orf27
Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family (454 aa)
           
  0.761
CPA5
M14 carboxypeptidases; Belongs to the peptidase M14 family (436 aa)
           
  0.665
ARNT2
Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE); Basic helix-loop-helix proteins (717 aa)
           
  0.646
USF1
Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5’-CACGTG-3’) that is found in a variety of viral and cellular promoters; Basic helix-loop-helix proteins (310 aa)
           
  0.612
FNDC1
Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing (1894 aa)
           
  0.556
MRPS33
Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family (106 aa)
       
      0.535
BHLHE40
Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1|ARNTL2/B [...] (412 aa)
           
  0.522
XRN2
5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (950 aa)
       
      0.520
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]