node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARNT2 | CARF | ENSP00000307479 | ENSP00000384006 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE); Basic helix-loop-helix proteins | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.646 |
BHLHE40 | CARF | ENSP00000256495 | ENSP00000384006 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1|ARNTL2/B [...] | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.522 |
BHLHE40 | USF1 | ENSP00000256495 | ENSP00000357000 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1|ARNTL2/B [...] | Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5’-CACGTG-3’) that is found in a variety of viral and cellular promoters; Basic helix-loop-helix proteins | 0.463 |
C1orf27 | CARF | ENSP00000287859 | ENSP00000384006 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.761 |
C1orf27 | CCDC173 | ENSP00000287859 | ENSP00000391504 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Coiled-coil domain containing 173 | 0.828 |
C1orf27 | FNDC1 | ENSP00000287859 | ENSP00000297267 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.647 |
CARF | ARNT2 | ENSP00000384006 | ENSP00000307479 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE); Basic helix-loop-helix proteins | 0.646 |
CARF | BHLHE40 | ENSP00000384006 | ENSP00000256495 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator- CLOCK-ARNTL/BMAL1|ARNTL2/B [...] | 0.522 |
CARF | C1orf27 | ENSP00000384006 | ENSP00000287859 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | 0.761 |
CARF | CCDC173 | ENSP00000384006 | ENSP00000391504 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Coiled-coil domain containing 173 | 0.775 |
CARF | CDC5L | ENSP00000384006 | ENSP00000360532 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | 0.980 |
CARF | CPA5 | ENSP00000384006 | ENSP00000420237 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | M14 carboxypeptidases; Belongs to the peptidase M14 family | 0.665 |
CARF | FNDC1 | ENSP00000384006 | ENSP00000297267 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.556 |
CARF | MRPS33 | ENSP00000384006 | ENSP00000376732 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family | 0.535 |
CARF | USF1 | ENSP00000384006 | ENSP00000357000 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5’-CACGTG-3’) that is found in a variety of viral and cellular promoters; Basic helix-loop-helix proteins | 0.612 |
CARF | XRN2 | ENSP00000384006 | ENSP00000366396 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites | 0.520 |
CCDC173 | C1orf27 | ENSP00000391504 | ENSP00000287859 | Coiled-coil domain containing 173 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family | 0.828 |
CCDC173 | CARF | ENSP00000391504 | ENSP00000384006 | Coiled-coil domain containing 173 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.775 |
CCDC173 | FNDC1 | ENSP00000391504 | ENSP00000297267 | Coiled-coil domain containing 173 | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing | 0.572 |
CDC5L | CARF | ENSP00000360532 | ENSP00000384006 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5’-CTATTTCGAG-3’ sequence | 0.980 |