Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EN1 | ZNF610 | ENSP00000295206 | ENSP00000383922 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.455 |
| PCDH1 | ZNF610 | ENSP00000287008 | ENSP00000383922 | Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion; Non-clustered protocadherins | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.431 |
| PCDH10 | ZNF610 | ENSP00000264360 | ENSP00000383922 | Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.480 |
| RPRM | ZNF610 | ENSP00000314946 | ENSP00000383922 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity) | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.400 |
| RSPO2 | ZNF610 | ENSP00000276659 | ENSP00000383922 | R-spondin-2; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP r [...] | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.534 |
| SORCS3 | ZNF610 | ENSP00000358715 | ENSP00000383922 | Sortilin related VPS10 domain containing receptor 3; Belongs to the VPS10-related sortilin family. SORCS subfamily | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.474 |
| TRIM28 | ZNF610 | ENSP00000253024 | ENSP00000383922 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.908 |
| ZNF610 | EN1 | ENSP00000383922 | ENSP00000295206 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | 0.455 |
| ZNF610 | PCDH1 | ENSP00000383922 | ENSP00000287008 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion; Non-clustered protocadherins | 0.431 |
| ZNF610 | PCDH10 | ENSP00000383922 | ENSP00000264360 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | 0.480 |
| ZNF610 | RPRM | ENSP00000383922 | ENSP00000314946 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity) | 0.400 |
| ZNF610 | RSPO2 | ENSP00000383922 | ENSP00000276659 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | R-spondin-2; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP r [...] | 0.534 |
| ZNF610 | SORCS3 | ENSP00000383922 | ENSP00000358715 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Sortilin related VPS10 domain containing receptor 3; Belongs to the VPS10-related sortilin family. SORCS subfamily | 0.474 |
| ZNF610 | TRIM28 | ENSP00000383922 | ENSP00000253024 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.908 |
