node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMFR | ERLIN1 | ENSP00000290649 | ENSP00000410964 | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into [...] | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | 0.925 |
AMFR | ERLIN2 | ENSP00000290649 | ENSP00000276461 | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into [...] | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | 0.935 |
AMFR | FAF2 | ENSP00000290649 | ENSP00000261942 | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into [...] | FAS-associated factor 2; Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis; UBX domain containing | 0.978 |
AMFR | UBAC2 | ENSP00000290649 | ENSP00000383911 | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into [...] | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family | 0.944 |
EMC1 | EMC2 | ENSP00000420608 | ENSP00000220853 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | 0.999 |
EMC1 | EMC3 | ENSP00000420608 | ENSP00000245046 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | ER membrane protein complex subunit 3 | 0.999 |
EMC1 | ERLIN1 | ENSP00000420608 | ENSP00000410964 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | 0.518 |
EMC1 | ERLIN2 | ENSP00000420608 | ENSP00000276461 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex | 0.470 |
EMC1 | FAF2 | ENSP00000420608 | ENSP00000261942 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | FAS-associated factor 2; Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis; UBX domain containing | 0.474 |
EMC1 | UBAC2 | ENSP00000420608 | ENSP00000383911 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family | 0.926 |
EMC2 | EMC1 | ENSP00000220853 | ENSP00000420608 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | ER membrane protein complex subunit 1; Belongs to the EMC1 family | 0.999 |
EMC2 | EMC3 | ENSP00000220853 | ENSP00000245046 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | ER membrane protein complex subunit 3 | 0.999 |
EMC2 | ERLIN1 | ENSP00000220853 | ENSP00000410964 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | 0.429 |
EMC2 | UBAC2 | ENSP00000220853 | ENSP00000383911 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family | 0.927 |
EMC3 | EMC1 | ENSP00000245046 | ENSP00000420608 | ER membrane protein complex subunit 3 | ER membrane protein complex subunit 1; Belongs to the EMC1 family | 0.999 |
EMC3 | EMC2 | ENSP00000245046 | ENSP00000220853 | ER membrane protein complex subunit 3 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | 0.999 |
EMC3 | UBAC2 | ENSP00000245046 | ENSP00000383911 | ER membrane protein complex subunit 3 | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family | 0.933 |
ERLIN1 | AMFR | ENSP00000410964 | ENSP00000290649 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into [...] | 0.925 |
ERLIN1 | EMC1 | ENSP00000410964 | ENSP00000420608 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | ER membrane protein complex subunit 1; Belongs to the EMC1 family | 0.518 |
ERLIN1 | EMC2 | ENSP00000410964 | ENSP00000220853 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex; Belongs to the band 7/mec-2 family | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing | 0.429 |