node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMH | DDX4 | ENSP00000221496 | ENSP00000424838 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Endogenous ligands | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] | 0.553 |
AMH | DMRTA2 | ENSP00000221496 | ENSP00000383909 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Endogenous ligands | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | 0.553 |
AMH | SOX2 | ENSP00000221496 | ENSP00000323588 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Endogenous ligands | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.481 |
DDX4 | AMH | ENSP00000424838 | ENSP00000221496 | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Endogenous ligands | 0.553 |
DDX4 | DMRTA2 | ENSP00000424838 | ENSP00000383909 | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | 0.476 |
DDX4 | SOX2 | ENSP00000424838 | ENSP00000323588 | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.453 |
DMRTA2 | AMH | ENSP00000383909 | ENSP00000221496 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin; Endogenous ligands | 0.553 |
DMRTA2 | DDX4 | ENSP00000383909 | ENSP00000424838 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ ce [...] | 0.476 |
DMRTA2 | KCNG2 | ENSP00000383909 | ENSP00000315654 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | 0.505 |
DMRTA2 | MED29 | ENSP00000383909 | ENSP00000314343 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.509 |
DMRTA2 | PAX6 | ENSP00000383909 | ENSP00000404100 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family | 0.685 |
DMRTA2 | PSMD10 | ENSP00000383909 | ENSP00000217958 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | 26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10-PSMC4-PSMC5-PAAF1 module which probably assembles with a PSMD5-PSMC2-PSMC1-PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis; Ankyrin repeat domain containing | 0.621 |
DMRTA2 | SOX2 | ENSP00000383909 | ENSP00000323588 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By si [...] | 0.599 |
DMRTA2 | TRA2A | ENSP00000383909 | ENSP00000297071 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing | 0.600 |
DMRTA2 | TXNL1 | ENSP00000383909 | ENSP00000217515 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV | 0.490 |
DMRTA2 | ZNF672 | ENSP00000383909 | ENSP00000421915 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | Zinc finger protein 672; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.586 |
KCNG2 | DMRTA2 | ENSP00000315654 | ENSP00000383909 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | 0.505 |
KCNG2 | PSMD10 | ENSP00000315654 | ENSP00000217958 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | 26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10-PSMC4-PSMC5-PAAF1 module which probably assembles with a PSMD5-PSMC2-PSMC1-PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis; Ankyrin repeat domain containing | 0.405 |
KCNG2 | TRA2A | ENSP00000315654 | ENSP00000297071 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily | Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing | 0.481 |
MED29 | DMRTA2 | ENSP00000314343 | ENSP00000383909 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development | 0.509 |