node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI2 | BAIAP2 | ENSP00000295851 | ENSP00000316338 | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | 0.939 |
ABI2 | KIAA1522 | ENSP00000295851 | ENSP00000383851 | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) | Uncharacterized protein KIAA1522; KIAA1522 | 0.625 |
ABI2 | NCK2 | ENSP00000295851 | ENSP00000233154 | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) | Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling; SH2 domain containing | 0.644 |
BAIAP2 | ABI2 | ENSP00000316338 | ENSP00000295851 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) | 0.939 |
BAIAP2 | KIAA1522 | ENSP00000316338 | ENSP00000383851 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | Uncharacterized protein KIAA1522; KIAA1522 | 0.868 |
BAIAP2 | NCK2 | ENSP00000316338 | ENSP00000233154 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling; SH2 domain containing | 0.687 |
C8orf33 | KIAA1522 | ENSP00000330361 | ENSP00000383851 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family | Uncharacterized protein KIAA1522; KIAA1522 | 0.538 |
C8orf33 | TSNAXIP1 | ENSP00000330361 | ENSP00000457241 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis | 0.585 |
GPR6 | KIAA1522 | ENSP00000406986 | ENSP00000383851 | G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity); G protein-coupled receptors, Class A orphans | Uncharacterized protein KIAA1522; KIAA1522 | 0.573 |
KIAA1522 | ABI2 | ENSP00000383851 | ENSP00000295851 | Uncharacterized protein KIAA1522; KIAA1522 | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) | 0.625 |
KIAA1522 | BAIAP2 | ENSP00000383851 | ENSP00000316338 | Uncharacterized protein KIAA1522; KIAA1522 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] | 0.868 |
KIAA1522 | C8orf33 | ENSP00000383851 | ENSP00000330361 | Uncharacterized protein KIAA1522; KIAA1522 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family | 0.538 |
KIAA1522 | GPR6 | ENSP00000383851 | ENSP00000406986 | Uncharacterized protein KIAA1522; KIAA1522 | G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity); G protein-coupled receptors, Class A orphans | 0.573 |
KIAA1522 | KLHL31 | ENSP00000383851 | ENSP00000359942 | Uncharacterized protein KIAA1522; KIAA1522 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE); BTB domain containing | 0.575 |
KIAA1522 | NCK2 | ENSP00000383851 | ENSP00000233154 | Uncharacterized protein KIAA1522; KIAA1522 | Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling; SH2 domain containing | 0.790 |
KIAA1522 | PCOLCE | ENSP00000383851 | ENSP00000223061 | Uncharacterized protein KIAA1522; KIAA1522 | Procollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.495 |
KIAA1522 | POGK | ENSP00000383851 | ENSP00000356849 | Uncharacterized protein KIAA1522; KIAA1522 | Pogo transposable element derived with KRAB domain; DNA transposon derived genes | 0.567 |
KIAA1522 | TSNAXIP1 | ENSP00000383851 | ENSP00000457241 | Uncharacterized protein KIAA1522; KIAA1522 | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis | 0.528 |
KIAA1522 | ZNF98 | ENSP00000383851 | ENSP00000350418 | Uncharacterized protein KIAA1522; KIAA1522 | Zinc finger protein 98; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.511 |
KLHL31 | KIAA1522 | ENSP00000359942 | ENSP00000383851 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE); BTB domain containing | Uncharacterized protein KIAA1522; KIAA1522 | 0.575 |