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  • 11.0 [archived version]
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BAIAP2 BAIAP2 ABI2 ABI2 NCK2 NCK2 KLHL31 KLHL31 GPR6 GPR6 KIAA1522 KIAA1522 ZNF98 ZNF98 POGK POGK C8orf33 C8orf33 TSNAXIP1 TSNAXIP1 PCOLCE PCOLCE
"KIAA1522" - Uncharacterized protein KIAA1522 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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KIAA1522Uncharacterized protein KIAA1522; KIAA1522 (1094 aa)    
Predicted Functional Partners:
BAIAP2
Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling [...] (552 aa)
     
      0.868
NCK2
Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling; SH2 domain containing (380 aa)
       
 
  0.790
ABI2
Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) (513 aa)
       
      0.625
KLHL31
Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE); BTB domain containing (634 aa)
           
  0.575
GPR6
G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity); G protein-coupled receptors, Class A orphans (377 aa)
           
  0.573
POGK
Pogo transposable element derived with KRAB domain; DNA transposon derived genes (609 aa)
           
  0.567
C8orf33
UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family (229 aa)
           
  0.538
TSNAXIP1
Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis (712 aa)
           
  0.528
ZNF98
Zinc finger protein 98; May be involved in transcriptional regulation; Zinc fingers C2H2-type (572 aa)
           
  0.511
PCOLCE
Procollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity (449 aa)
           
  0.495
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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