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STRINGSTRING
DQX1 DQX1 C2orf54 C2orf54 C1orf50 C1orf50 SLC37A1 SLC37A1 LCE1D LCE1D KLHDC7A KLHDC7A MKLN1 MKLN1 C21orf58 C21orf58 KLHDC10 KLHDC10 FAM124A FAM124A KLHL40 KLHL40
"KLHDC7A" - Kelch domain containing 7A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
Coexpression
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[Homology]
Score
KLHDC7AKelch domain containing 7A (777 aa)    
Predicted Functional Partners:
KLHL40
Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F-DP transcription factor complex (By similarity). Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear (By similarity) (621 aa)
      
   
  0.709
KLHDC10
Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (442 aa)
            
  0.636
MKLN1
Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex (735 aa)
            
  0.601
DQX1
ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1 (717 aa)
            
  0.546
FAM124A
Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family (582 aa)
            
  0.527
C1orf50
Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50 (199 aa)
            
  0.519
C21orf58
Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58 (322 aa)
            
  0.517
LCE1D
Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum (114 aa)
            
  0.514
SLC37A1
Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6- phosphatase. May not play a role in homeostatic regulation of blood glucose levels; Belongs to the major facilitator superfamily. Organophosphate-Pi antiporter (OPA) (TC 2.A.1.4) family (533 aa)
      
   
  0.512
C2orf54
Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 (447 aa)
            
  0.503
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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