| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| A1BG | GAB4 | ENSP00000263100 | ENSP00000383431 | Alpha-1B-glycoprotein; Immunoglobulin like domain containing | GRB2 associated binding protein family member 4; Belongs to the GAB family | 0.543 |
| A1BG | GRB2 | ENSP00000263100 | ENSP00000376345 | Alpha-1B-glycoprotein; Immunoglobulin like domain containing | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.965 |
| A1BG | PTPN11 | ENSP00000263100 | ENSP00000340944 | Alpha-1B-glycoprotein; Immunoglobulin like domain containing | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.959 |
| A1BG | SHC1 | ENSP00000263100 | ENSP00000401303 | Alpha-1B-glycoprotein; Immunoglobulin like domain containing | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | 0.446 |
| C2CD4D | GAB4 | ENSP00000389554 | ENSP00000383431 | C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D | GRB2 associated binding protein family member 4; Belongs to the GAB family | 0.583 |
| C2CD4D | OR2B11 | ENSP00000389554 | ENSP00000325682 | C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D | Olfactory receptor 2B11; Odorant receptor; Olfactory receptors, family 2 | 0.668 |
| C2CD4D | ZSCAN30 | ENSP00000389554 | ENSP00000392371 | C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D | Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation; SCAN domain containing | 0.644 |
| FYN | GAB4 | ENSP00000346671 | ENSP00000383431 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | GRB2 associated binding protein family member 4; Belongs to the GAB family | 0.587 |
| FYN | GRB2 | ENSP00000346671 | ENSP00000376345 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.967 |
| FYN | LYN | ENSP00000346671 | ENSP00000428924 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B- [...] | 0.905 |
| FYN | PTPN11 | ENSP00000346671 | ENSP00000340944 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.965 |
| FYN | SHC1 | ENSP00000346671 | ENSP00000401303 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...] | 0.982 |
| FYN | SYK | ENSP00000346671 | ENSP00000364907 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can [...] | 0.951 |
| GAB4 | A1BG | ENSP00000383431 | ENSP00000263100 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Alpha-1B-glycoprotein; Immunoglobulin like domain containing | 0.543 |
| GAB4 | C2CD4D | ENSP00000383431 | ENSP00000389554 | GRB2 associated binding protein family member 4; Belongs to the GAB family | C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D | 0.583 |
| GAB4 | FYN | ENSP00000383431 | ENSP00000346671 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.587 |
| GAB4 | GRB2 | ENSP00000383431 | ENSP00000376345 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing | 0.927 |
| GAB4 | LYN | ENSP00000383431 | ENSP00000428924 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down- regulation and termination. Plays an important role in the regulation of B- [...] | 0.669 |
| GAB4 | OR2B11 | ENSP00000383431 | ENSP00000325682 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Olfactory receptor 2B11; Odorant receptor; Olfactory receptors, family 2 | 0.543 |
| GAB4 | PTPN11 | ENSP00000383431 | ENSP00000340944 | GRB2 associated binding protein family member 4; Belongs to the GAB family | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at ’Tyr-722’ resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73; Protein tyrosine phosphatases, non-receptor type | 0.896 |
