| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HSPA13 | LIPI | ENSP00000285667 | ENSP00000343331 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family | 0.710 |
| HSPA13 | RBM11 | ENSP00000285667 | ENSP00000383421 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.593 |
| HSPA13 | RBM17 | ENSP00000285667 | ENSP00000388638 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | Splicing factor 45; Splice factor that binds to the single-stranded 3’AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia; G-patch domain containing | 0.501 |
| LIPI | HSPA13 | ENSP00000343331 | ENSP00000285667 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 0.710 |
| LIPI | RBM11 | ENSP00000343331 | ENSP00000383421 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.606 |
| NOVA1 | RBM11 | ENSP00000438875 | ENSP00000383421 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.601 |
| NOVA1 | SCAF4 | ENSP00000438875 | ENSP00000286835 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | Splicing factor, arginine/serine-rich 15; May act to physically and functionally link transcription and pre-mRNA processing; Belongs to the splicing factor SR family | 0.624 |
| PCBP3 | RBM11 | ENSP00000383168 | ENSP00000383421 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.720 |
| PCBP3 | SCAF4 | ENSP00000383168 | ENSP00000286835 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Splicing factor, arginine/serine-rich 15; May act to physically and functionally link transcription and pre-mRNA processing; Belongs to the splicing factor SR family | 0.682 |
| RBM11 | HSPA13 | ENSP00000383421 | ENSP00000285667 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins | 0.593 |
| RBM11 | LIPI | ENSP00000383421 | ENSP00000343331 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG); Belongs to the AB hydrolase superfamily. Lipase family | 0.606 |
| RBM11 | NOVA1 | ENSP00000383421 | ENSP00000438875 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons | 0.601 |
| RBM11 | PCBP3 | ENSP00000383421 | ENSP00000383168 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.720 |
| RBM11 | RBM15 | ENSP00000383421 | ENSP00000358799 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Putative RNA-binding protein 15; May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation; Belongs to the RRM Spen family | 0.635 |
| RBM11 | RBM17 | ENSP00000383421 | ENSP00000388638 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Splicing factor 45; Splice factor that binds to the single-stranded 3’AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia; G-patch domain containing | 0.717 |
| RBM11 | RBM19 | ENSP00000383421 | ENSP00000442053 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development; RNA binding motif containing | 0.605 |
| RBM11 | RBM25 | ENSP00000383421 | ENSP00000261973 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5’-splice site (5’-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5’-ss usage through the 5’-CGGGCA-3’ RNA sequence. Its association with LUC7 [...] | 0.728 |
| RBM11 | SCAF4 | ENSP00000383421 | ENSP00000286835 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Splicing factor, arginine/serine-rich 15; May act to physically and functionally link transcription and pre-mRNA processing; Belongs to the splicing factor SR family | 0.664 |
| RBM11 | ZCCHC8 | ENSP00000383421 | ENSP00000438993 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non- coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein adapters. May be involved in pre-mRNA splicing (Probable) | 0.856 |
| RBM15 | RBM11 | ENSP00000358799 | ENSP00000383421 | Putative RNA-binding protein 15; May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation; Belongs to the RRM Spen family | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.635 |
