node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG4 | HSPA1L | ENSP00000287322 | ENSP00000364805 | BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria; BCL2 associated athanogene family | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.959 |
BAG4 | SIAH3 | ENSP00000287322 | ENSP00000383256 | BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria; BCL2 associated athanogene family | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.658 |
BAG4 | TOMM7 | ENSP00000287322 | ENSP00000351214 | BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria; BCL2 associated athanogene family | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria; Belongs to the Tom7 family | 0.599 |
FAM217A | OR6M1 | ENSP00000274673 | ENSP00000311038 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 | 0.669 |
FAM217A | OR8H3 | ENSP00000274673 | ENSP00000323928 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 | 0.668 |
FAM217A | RSPH10B2 | ENSP00000274673 | ENSP00000384766 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | Radial spoke head 10 homolog B2 | 0.640 |
FAM217A | SIAH3 | ENSP00000274673 | ENSP00000383256 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.534 |
HSPA1L | BAG4 | ENSP00000364805 | ENSP00000287322 | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria; BCL2 associated athanogene family | 0.959 |
HSPA1L | SIAH3 | ENSP00000364805 | ENSP00000383256 | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.591 |
HSPA1L | TOMM7 | ENSP00000364805 | ENSP00000351214 | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria; Belongs to the Tom7 family | 0.489 |
IGFL3 | SIAH3 | ENSP00000344860 | ENSP00000383256 | Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.526 |
OR6M1 | FAM217A | ENSP00000311038 | ENSP00000274673 | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | 0.669 |
OR6M1 | RSPH10B2 | ENSP00000311038 | ENSP00000384766 | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 | Radial spoke head 10 homolog B2 | 0.587 |
OR6M1 | SIAH3 | ENSP00000311038 | ENSP00000383256 | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.511 |
OR8H3 | FAM217A | ENSP00000323928 | ENSP00000274673 | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | 0.668 |
OR8H3 | RSPH10B2 | ENSP00000323928 | ENSP00000384766 | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 | Radial spoke head 10 homolog B2 | 0.585 |
OR8H3 | SIAH3 | ENSP00000323928 | ENSP00000383256 | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria | 0.510 |
RSPH10B2 | FAM217A | ENSP00000384766 | ENSP00000274673 | Radial spoke head 10 homolog B2 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family | 0.640 |
RSPH10B2 | OR6M1 | ENSP00000384766 | ENSP00000311038 | Radial spoke head 10 homolog B2 | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 | 0.587 |
RSPH10B2 | OR8H3 | ENSP00000384766 | ENSP00000323928 | Radial spoke head 10 homolog B2 | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 | 0.585 |