node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF4B | PCBP3 | ENSP00000388806 | ENSP00000383168 | Eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.539 |
LRRFIP1 | PCBP3 | ENSP00000375857 | ENSP00000383168 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.570 |
LRRFIP1 | PRPSAP1 | ENSP00000375857 | ENSP00000414624 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.494 |
LRRFIP1 | SYT5 | ENSP00000375857 | ENSP00000346265 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity); Synaptotagmins | 0.533 |
LRRFIP1 | TOMM70A | ENSP00000375857 | ENSP00000284320 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins | 0.449 |
NFIB | PCBP3 | ENSP00000370340 | ENSP00000383168 | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.528 |
PCBP3 | EIF4B | ENSP00000383168 | ENSP00000388806 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5’- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F | 0.539 |
PCBP3 | LRRFIP1 | ENSP00000383168 | ENSP00000375857 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | 0.570 |
PCBP3 | NFIB | ENSP00000383168 | ENSP00000370340 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family | 0.528 |
PCBP3 | PRPSAP1 | ENSP00000383168 | ENSP00000414624 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | 0.604 |
PCBP3 | RBM11 | ENSP00000383168 | ENSP00000383421 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5’ splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1 | 0.720 |
PCBP3 | RGSL1 | ENSP00000383168 | ENSP00000457748 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Regulator of G protein signaling like 1 | 0.559 |
PCBP3 | SCAF4 | ENSP00000383168 | ENSP00000286835 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Splicing factor, arginine/serine-rich 15; May act to physically and functionally link transcription and pre-mRNA processing; Belongs to the splicing factor SR family | 0.682 |
PCBP3 | SYT5 | ENSP00000383168 | ENSP00000346265 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity); Synaptotagmins | 0.670 |
PCBP3 | TOMM70A | ENSP00000383168 | ENSP00000284320 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins | 0.593 |
PCBP3 | ZCRB1 | ENSP00000383168 | ENSP00000266529 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | Zinc finger CCHC-type and RNA binding motif containing 1 | 0.617 |
PRPSAP1 | LRRFIP1 | ENSP00000414624 | ENSP00000375857 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | 0.494 |
PRPSAP1 | PCBP3 | ENSP00000414624 | ENSP00000383168 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC | 0.604 |
PRPSAP1 | SYT5 | ENSP00000414624 | ENSP00000346265 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity); Synaptotagmins | 0.597 |
PRPSAP1 | TOMM70A | ENSP00000414624 | ENSP00000284320 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins | 0.506 |