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  • 11.0 [archived version]
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RIC1 RIC1 TMPRSS12 TMPRSS12 MEIOB MEIOB CLDN16 CLDN16 NUDT11 NUDT11 KIAA2026 KIAA2026 UBTD1 UBTD1 MOCOS MOCOS C1orf174 C1orf174 HAGHL HAGHL CSRNP2 CSRNP2
"KIAA2026" - Uncharacterized protein KIAA2026 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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KIAA2026Uncharacterized protein KIAA2026; KIAA2026 (2103 aa)    
Predicted Functional Partners:
UBTD1
Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2 (227 aa)
       
 
  0.861
MEIOB
Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] (471 aa)
           
  0.696
C1orf174
UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family (243 aa)
           
  0.571
CLDN16
Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins (305 aa)
           
  0.542
NUDT11
Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; Belongs to the Nudix hydrolase family. DIPP subfamily (164 aa)
           
  0.537
TMPRSS12
Transmembrane serine protease 12; Belongs to the peptidase S1 family (348 aa)
           
  0.531
MOCOS
Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily (888 aa)
           
  0.527
HAGHL
Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds (282 aa)
           
  0.526
CSRNP2
Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits (543 aa)
           
  0.473
RIC1
RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing (1423 aa)
     
   
  0.451
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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