node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf174 | CSRNP2 | ENSP00000355306 | ENSP00000228515 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | 0.556 |
C1orf174 | HAGHL | ENSP00000355306 | ENSP00000374353 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.587 |
C1orf174 | KIAA2026 | ENSP00000355306 | ENSP00000382815 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | Uncharacterized protein KIAA2026; KIAA2026 | 0.571 |
CLDN16 | KIAA2026 | ENSP00000264734 | ENSP00000382815 | Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins | Uncharacterized protein KIAA2026; KIAA2026 | 0.542 |
CSRNP2 | C1orf174 | ENSP00000228515 | ENSP00000355306 | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | 0.556 |
CSRNP2 | HAGHL | ENSP00000228515 | ENSP00000374353 | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.596 |
CSRNP2 | KIAA2026 | ENSP00000228515 | ENSP00000382815 | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | Uncharacterized protein KIAA2026; KIAA2026 | 0.473 |
HAGHL | C1orf174 | ENSP00000374353 | ENSP00000355306 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | 0.587 |
HAGHL | CSRNP2 | ENSP00000374353 | ENSP00000228515 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | 0.596 |
HAGHL | KIAA2026 | ENSP00000374353 | ENSP00000382815 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Uncharacterized protein KIAA2026; KIAA2026 | 0.526 |
KIAA2026 | C1orf174 | ENSP00000382815 | ENSP00000355306 | Uncharacterized protein KIAA2026; KIAA2026 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family | 0.571 |
KIAA2026 | CLDN16 | ENSP00000382815 | ENSP00000264734 | Uncharacterized protein KIAA2026; KIAA2026 | Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors; Claudins | 0.542 |
KIAA2026 | CSRNP2 | ENSP00000382815 | ENSP00000228515 | Uncharacterized protein KIAA2026; KIAA2026 | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase 1 regulatory subunits | 0.473 |
KIAA2026 | HAGHL | ENSP00000382815 | ENSP00000374353 | Uncharacterized protein KIAA2026; KIAA2026 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.526 |
KIAA2026 | MEIOB | ENSP00000382815 | ENSP00000390778 | Uncharacterized protein KIAA2026; KIAA2026 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3’-5’ exonuclease activity i [...] | 0.696 |
KIAA2026 | MOCOS | ENSP00000382815 | ENSP00000261326 | Uncharacterized protein KIAA2026; KIAA2026 | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily | 0.527 |
KIAA2026 | NUDT11 | ENSP00000382815 | ENSP00000365160 | Uncharacterized protein KIAA2026; KIAA2026 | Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; Belongs to the Nudix hydrolase family. DIPP subfamily | 0.537 |
KIAA2026 | RIC1 | ENSP00000382815 | ENSP00000416696 | Uncharacterized protein KIAA2026; KIAA2026 | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1; WD repeat domain containing | 0.451 |
KIAA2026 | TMPRSS12 | ENSP00000382815 | ENSP00000381476 | Uncharacterized protein KIAA2026; KIAA2026 | Transmembrane serine protease 12; Belongs to the peptidase S1 family | 0.531 |
KIAA2026 | UBTD1 | ENSP00000382815 | ENSP00000359698 | Uncharacterized protein KIAA2026; KIAA2026 | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2 | 0.861 |