| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACADM | ATP8A1 | ENSP00000359871 | ENSP00000371084 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | 0.644 |
| ACADM | GRXCR1 | ENSP00000359871 | ENSP00000382670 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.755 |
| ANKRD24 | GIPC3 | ENSP00000471252 | ENSP00000319254 | Ankyrin repeat domain-containing protein 24; Ankyrin repeat domain containing | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | 0.618 |
| ANKRD24 | GRXCR1 | ENSP00000471252 | ENSP00000382670 | Ankyrin repeat domain-containing protein 24; Ankyrin repeat domain containing | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.676 |
| ATP8A1 | ACADM | ENSP00000371084 | ENSP00000359871 | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 0.644 |
| ATP8A1 | GRXCR1 | ENSP00000371084 | ENSP00000382670 | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1-TMEM30A seems to play a role in r [...] | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.905 |
| CAP1 | CAP2 | ENSP00000361883 | ENSP00000229922 | Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family | Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family | 0.926 |
| CAP1 | GRXCR1 | ENSP00000361883 | ENSP00000382670 | Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.732 |
| CAP2 | CAP1 | ENSP00000229922 | ENSP00000361883 | Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family | Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity; Belongs to the CAP family | 0.926 |
| CAP2 | GRXCR1 | ENSP00000229922 | ENSP00000382670 | Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.943 |
| DFNB59 | GIPC3 | ENSP00000386647 | ENSP00000319254 | Pejvakin; Essential in the activity of auditory pathway neurons | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | 0.788 |
| DFNB59 | GRXCR1 | ENSP00000386647 | ENSP00000382670 | Pejvakin; Essential in the activity of auditory pathway neurons | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.652 |
| DFNB59 | TMPRSS3 | ENSP00000386647 | ENSP00000291532 | Pejvakin; Essential in the activity of auditory pathway neurons | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro); Belongs to the peptidase S1 family | 0.679 |
| GIPC3 | ANKRD24 | ENSP00000319254 | ENSP00000471252 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | Ankyrin repeat domain-containing protein 24; Ankyrin repeat domain containing | 0.618 |
| GIPC3 | DFNB59 | ENSP00000319254 | ENSP00000386647 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | Pejvakin; Essential in the activity of auditory pathway neurons | 0.788 |
| GIPC3 | GRXCR1 | ENSP00000319254 | ENSP00000382670 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.682 |
| GIPC3 | TMPRSS3 | ENSP00000319254 | ENSP00000291532 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro); Belongs to the peptidase S1 family | 0.598 |
| GLRX | GRXCR1 | ENSP00000369314 | ENSP00000382670 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain containing | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | 0.763 |
| GLRX | SERINC3 | ENSP00000369314 | ENSP00000340243 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain containing | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1- acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm; Belongs to the TDE1 family | 0.533 |
| GRXCR1 | ACADM | ENSP00000382670 | ENSP00000359871 | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 0.755 |
