ANKRD18A protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ANKRD18A

Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing (992 aa)

Predicted Functional Partners:

ZNF541

0.585

FAM196A

0.581

NOP9

0.564

TMEM132E

0.529

ZNF280D

0.518

ANKRD34A

0.511

RIMKLB

0.497

ZNF280B

0.491

FAM63A

0.489

GAREM

0.450

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD18A	ANKRD34A	ENSP00000382610	ENSP00000475189	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Ankyrin repeat domain-containing protein 34A; Ankyrin repeat domain containing; Belongs to the ANKRD34 family	0.511
ANKRD18A	FAM196A	ENSP00000382610	ENSP00000429763	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Protein FAM196A; Family with sequence similarity 196 member A	0.581
ANKRD18A	FAM63A	ENSP00000382610	ENSP00000354669	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover; Belongs to the peptidase MINDY family. FAM63 subfamily	0.489
ANKRD18A	GAREM	ENSP00000382610	ENSP00000269209	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family	0.450
ANKRD18A	NOP9	ENSP00000382610	ENSP00000267425	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Nucleolar protein 9; Armadillo-like helical domain containing	0.564
ANKRD18A	RIMKLB	ENSP00000382610	ENSP00000350136	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate	0.497
ANKRD18A	TMEM132E	ENSP00000382610	ENSP00000316532	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family	0.529
ANKRD18A	ZNF280B	ENSP00000382610	ENSP00000480958	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Zinc finger protein 280B; May function as a transcription factor	0.491
ANKRD18A	ZNF280D	ENSP00000382610	ENSP00000267807	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Zinc finger protein 280D; May function as a transcription factor	0.518
ANKRD18A	ZNF541	ENSP00000382610	ENSP00000375770	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis; Myb/SANT domain containing	0.585
ANKRD34A	ANKRD18A	ENSP00000475189	ENSP00000382610	Ankyrin repeat domain-containing protein 34A; Ankyrin repeat domain containing; Belongs to the ANKRD34 family	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	0.511
FAM196A	ANKRD18A	ENSP00000429763	ENSP00000382610	Protein FAM196A; Family with sequence similarity 196 member A	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	0.581
FAM196A	GAREM	ENSP00000429763	ENSP00000269209	Protein FAM196A; Family with sequence similarity 196 member A	GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family	0.539
FAM196A	TMEM132E	ENSP00000429763	ENSP00000316532	Protein FAM196A; Family with sequence similarity 196 member A	Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family	0.574
FAM196A	ZNF541	ENSP00000429763	ENSP00000375770	Protein FAM196A; Family with sequence similarity 196 member A	Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis; Myb/SANT domain containing	0.588
FAM63A	ANKRD18A	ENSP00000354669	ENSP00000382610	Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover; Belongs to the peptidase MINDY family. FAM63 subfamily	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	0.489
FAM63A	NOP9	ENSP00000354669	ENSP00000267425	Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover; Belongs to the peptidase MINDY family. FAM63 subfamily	Nucleolar protein 9; Armadillo-like helical domain containing	0.533
FAM63A	RIMKLB	ENSP00000354669	ENSP00000350136	Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover; Belongs to the peptidase MINDY family. FAM63 subfamily	Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate	0.450
FAM63A	ZNF280D	ENSP00000354669	ENSP00000267807	Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove ’Lys-48’-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover; Belongs to the peptidase MINDY family. FAM63 subfamily	Zinc finger protein 280D; May function as a transcription factor	0.440
GAREM	ANKRD18A	ENSP00000269209	ENSP00000382610	GRB2-associated and regulator of MAPK protein 1; Isoform 1- Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation; Belongs to the GAREM family	Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing	0.450

page 1 of 3

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About