| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC3 | ENKUR | ENSP00000298032 | ENSP00000331044 | Armadillo repeat containing 3 | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | 0.537 |
| ARMC3 | ODF3 | ENSP00000298032 | ENSP00000325868 | Armadillo repeat containing 3 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail | 0.412 |
| ARMC3 | TSSK2 | ENSP00000298032 | ENSP00000382544 | Armadillo repeat containing 3 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.510 |
| ENKUR | ARMC3 | ENSP00000331044 | ENSP00000298032 | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | Armadillo repeat containing 3 | 0.537 |
| ENKUR | ODF3 | ENSP00000331044 | ENSP00000325868 | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail | 0.432 |
| ENKUR | TSSK2 | ENSP00000331044 | ENSP00000382544 | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.496 |
| MOS | PKMYT1 | ENSP00000310722 | ENSP00000262300 | MOS proto-oncogene, serine/threonine kinase | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development; Protein phosphatase 1 regulatory subunits | 0.848 |
| MOS | TSSK2 | ENSP00000310722 | ENSP00000382544 | MOS proto-oncogene, serine/threonine kinase | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.505 |
| ODF3 | ARMC3 | ENSP00000325868 | ENSP00000298032 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail | Armadillo repeat containing 3 | 0.412 |
| ODF3 | ENKUR | ENSP00000325868 | ENSP00000331044 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | 0.432 |
| ODF3 | TSSK2 | ENSP00000325868 | ENSP00000382544 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.491 |
| PACRG | TSSK2 | ENSP00000337946 | ENSP00000382544 | Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease; Armadillo-like helical domain containing | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.478 |
| PACRG | TXN2 | ENSP00000337946 | ENSP00000216185 | Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease; Armadillo-like helical domain containing | Thioredoxin, mitochondrial; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity; Belongs to the thioredoxin family | 0.518 |
| PKMYT1 | MOS | ENSP00000262300 | ENSP00000310722 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development; Protein phosphatase 1 regulatory subunits | MOS proto-oncogene, serine/threonine kinase | 0.848 |
| PKMYT1 | TSSK2 | ENSP00000262300 | ENSP00000382544 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development; Protein phosphatase 1 regulatory subunits | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.473 |
| SIPA1L1 | TSSK2 | ENSP00000450832 | ENSP00000382544 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity); PDZ domain containing | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.484 |
| TSKS | TSSK2 | ENSP00000246801 | ENSP00000382544 | Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development; Protein phosphatase 1 regulatory subunits | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.768 |
| TSSK2 | ARMC3 | ENSP00000382544 | ENSP00000298032 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | Armadillo repeat containing 3 | 0.510 |
| TSSK2 | ENKUR | ENSP00000382544 | ENSP00000331044 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated | 0.496 |
| TSSK2 | MOS | ENSP00000382544 | ENSP00000310722 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | MOS proto-oncogene, serine/threonine kinase | 0.505 |
