| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP5Z1 | RADIL | ENSP00000297562 | ENSP00000382492 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.659 |
| AP5Z1 | RRAS2 | ENSP00000297562 | ENSP00000256196 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion | 0.489 |
| AP5Z1 | SNX9 | ENSP00000297562 | ENSP00000376024 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | 0.421 |
| ARHGAP29 | RADIL | ENSP00000260526 | ENSP00000382492 | Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.646 |
| C16orf59 | RADIL | ENSP00000355022 | ENSP00000382492 | Uncharacterized protein C16orf59; Chromosome 16 open reading frame 59 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.525 |
| C16orf59 | SERTM1 | ENSP00000355022 | ENSP00000325776 | Uncharacterized protein C16orf59; Chromosome 16 open reading frame 59 | Serine rich and transmembrane domain containing 1 | 0.776 |
| FAM171A1 | RADIL | ENSP00000367356 | ENSP00000382492 | Protein FAM171A1; Family with sequence similarity 171 member A1 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.619 |
| ISOC2 | RADIL | ENSP00000085068 | ENSP00000382492 | Isochorismatase domain containing 2 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.549 |
| P2RY10 | RADIL | ENSP00000171757 | ENSP00000382492 | Putative P2Y purinoceptor 10; Putative receptor for purines coupled to G-proteins | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.631 |
| RADIL | AP5Z1 | ENSP00000382492 | ENSP00000297562 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair; Armadillo-like helical domain containing | 0.659 |
| RADIL | ARHGAP29 | ENSP00000382492 | ENSP00000260526 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis | 0.646 |
| RADIL | C16orf59 | ENSP00000382492 | ENSP00000355022 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Uncharacterized protein C16orf59; Chromosome 16 open reading frame 59 | 0.525 |
| RADIL | FAM171A1 | ENSP00000382492 | ENSP00000367356 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Protein FAM171A1; Family with sequence similarity 171 member A1 | 0.619 |
| RADIL | ISOC2 | ENSP00000382492 | ENSP00000085068 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Isochorismatase domain containing 2 | 0.549 |
| RADIL | P2RY10 | ENSP00000382492 | ENSP00000171757 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Putative P2Y purinoceptor 10; Putative receptor for purines coupled to G-proteins | 0.631 |
| RADIL | RAP1A | ENSP00000382492 | ENSP00000358723 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial grow [...] | 0.800 |
| RADIL | RRAS2 | ENSP00000382492 | ENSP00000256196 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion | 0.667 |
| RADIL | SERTM1 | ENSP00000382492 | ENSP00000325776 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Serine rich and transmembrane domain containing 1 | 0.531 |
| RADIL | SNX9 | ENSP00000382492 | ENSP00000376024 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promot [...] | 0.514 |
| RAP1A | RADIL | ENSP00000358723 | ENSP00000382492 | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial grow [...] | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL family | 0.800 |
