| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AIFM3 | DAO | ENSP00000382120 | ENSP00000228476 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids; Belongs to the DAMOX/DASOX family | 0.544 |
| AIFM3 | FAM131C | ENSP00000382120 | ENSP00000364814 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Protein FAM131C; Family with sequence similarity 131 member C | 0.670 |
| AIFM3 | LZTR1 | ENSP00000382120 | ENSP00000215739 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Leucine-zipper-like transcriptional regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis; BTB domain containing | 0.778 |
| AIFM3 | MRPL40 | ENSP00000382120 | ENSP00000333401 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | 0.589 |
| AIFM3 | OGG1 | ENSP00000382120 | ENSP00000306561 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | N-glycosylase/DNA lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3’ to the lesion; Belongs to the type-1 OGG1 family | 0.517 |
| AIFM3 | SNAP29 | ENSP00000382120 | ENSP00000215730 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions; Belongs to the SNAP-25 family | 0.650 |
| AIFM3 | STK32A | ENSP00000382120 | ENSP00000381535 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Serine/threonine kinase 32A | 0.621 |
| AIFM3 | SUOX | ENSP00000382120 | ENSP00000377668 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Sulfite oxidase, mitochondrial; Sulfite oxidase | 0.532 |
| AIFM3 | TANGO2 | ENSP00000382120 | ENSP00000403645 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Transport and golgi organization 2 homolog | 0.550 |
| AIFM3 | TRMT2A | ENSP00000382120 | ENSP00000252136 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; tRNA methyltransferases | 0.542 |
| DAO | AIFM3 | ENSP00000228476 | ENSP00000382120 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids; Belongs to the DAMOX/DASOX family | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.544 |
| FAM131C | AIFM3 | ENSP00000364814 | ENSP00000382120 | Protein FAM131C; Family with sequence similarity 131 member C | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.670 |
| FAM131C | STK32A | ENSP00000364814 | ENSP00000381535 | Protein FAM131C; Family with sequence similarity 131 member C | Serine/threonine kinase 32A | 0.813 |
| LZTR1 | AIFM3 | ENSP00000215739 | ENSP00000382120 | Leucine-zipper-like transcriptional regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis; BTB domain containing | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.778 |
| LZTR1 | SNAP29 | ENSP00000215739 | ENSP00000215730 | Leucine-zipper-like transcriptional regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis; BTB domain containing | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions; Belongs to the SNAP-25 family | 0.473 |
| MRPL40 | AIFM3 | ENSP00000333401 | ENSP00000382120 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.589 |
| MRPL40 | TANGO2 | ENSP00000333401 | ENSP00000403645 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | Transport and golgi organization 2 homolog | 0.785 |
| MRPL40 | TRMT2A | ENSP00000333401 | ENSP00000252136 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; tRNA methyltransferases | 0.654 |
| OGG1 | AIFM3 | ENSP00000306561 | ENSP00000382120 | N-glycosylase/DNA lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3’ to the lesion; Belongs to the type-1 OGG1 family | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.517 |
| SNAP29 | AIFM3 | ENSP00000215730 | ENSP00000382120 | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions; Belongs to the SNAP-25 family | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.650 |
