| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CSMD1 | DOPEY2 | ENSP00000430733 | ENSP00000382104 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.750 |
| CSMD1 | HNRNPCL1 | ENSP00000430733 | ENSP00000479365 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing | 0.597 |
| CSMD1 | IMMP2L | ENSP00000430733 | ENSP00000384966 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | 0.665 |
| CSMD1 | SLC35F2 | ENSP00000430733 | ENSP00000436785 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | Solute carrier family 35 member F2; Putative solute transporter | 0.794 |
| DCAF12 | DOPEY2 | ENSP00000355114 | ENSP00000382104 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.579 |
| DCAF12 | FBXO7 | ENSP00000355114 | ENSP00000266087 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination; F-boxes other | 0.576 |
| DOPEY2 | CSMD1 | ENSP00000382104 | ENSP00000430733 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | 0.750 |
| DOPEY2 | DCAF12 | ENSP00000382104 | ENSP00000355114 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.579 |
| DOPEY2 | FBXO7 | ENSP00000382104 | ENSP00000266087 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination; F-boxes other | 0.572 |
| DOPEY2 | HNRNPCL1 | ENSP00000382104 | ENSP00000479365 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing | 0.618 |
| DOPEY2 | IMMP2L | ENSP00000382104 | ENSP00000384966 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | 0.740 |
| DOPEY2 | MON2 | ENSP00000382104 | ENSP00000377250 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.858 |
| DOPEY2 | MRPS6 | ENSP00000382104 | ENSP00000382250 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Mitochondrial ribosomal protein S6 | 0.593 |
| DOPEY2 | SLC35F2 | ENSP00000382104 | ENSP00000436785 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Solute carrier family 35 member F2; Putative solute transporter | 0.794 |
| DOPEY2 | TMEM50B | ENSP00000382104 | ENSP00000439768 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Transmembrane protein 50B | 0.604 |
| DOPEY2 | TRIP12 | ENSP00000382104 | ENSP00000373696 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] | 0.769 |
| FBXO7 | DCAF12 | ENSP00000266087 | ENSP00000355114 | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination; F-boxes other | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.576 |
| FBXO7 | DOPEY2 | ENSP00000266087 | ENSP00000382104 | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination; F-boxes other | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.572 |
| FBXO7 | TRIP12 | ENSP00000266087 | ENSP00000373696 | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination; F-boxes other | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in [...] | 0.926 |
| HNRNPCL1 | CSMD1 | ENSP00000479365 | ENSP00000430733 | Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits | 0.597 |
