• Version:
  • 11.0 [archived version]
STRINGSTRING
C5orf30 C5orf30 RAG2 RAG2 KRBA2 KRBA2 HARBI1 HARBI1 GIN1 GIN1 THAP9 THAP9 PGBD5 PGBD5 EFCAB2 EFCAB2 GALNT2 GALNT2 COG2 COG2 HNRNPU HNRNPU
"GIN1" - Gypsy retrotransposon integrase 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
GIN1Gypsy retrotransposon integrase 1 (522 aa)    
Predicted Functional Partners:
PGBD5
PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene; DNA transposon derived genes (455 aa)
           
  0.749
THAP9
DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition; THAP domain containing (903 aa)
     
   
  0.724
HARBI1
Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity; DNA transposon derived genes (349 aa)
           
  0.716
EFCAB2
EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated (162 aa)
     
   
  0.694
COG2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family (738 aa)
           
  0.634
KRBA2
KRAB-A domain containing 2 (492 aa)
           
  0.587
GALNT2
Polypeptide N-acetylgalactosaminyltransferase 2; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily (571 aa)
           
  0.574
C5orf30
UNC119-binding protein C5orf30; Probably plays a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters- may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells (206 aa)
           
  0.570
RAG2
V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps- a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3’-hydroxyl group that can attack the pho [...] (527 aa)
           
  0.563
HNRNPU
Heterogeneous nuclear ribonucleoprotein U; DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin- associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability. Required for the localization of the long non-coding Xist RNA on the inacti [...] (825 aa)
           
  0.555
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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