C4orf29 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

C4orf29

Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily (414 aa)

Predicted Functional Partners:

C6orf165

0.630

RBBP9

0.622

ESF1

0.564

PLEKHH1

0.559

SELO

0.519

POLR3GL

0.503

INTU

0.503

BLCAP

0.502

SDR16C5

0.474

CLCA4

0.440

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLCAP	C4orf29	ENSP00000397172	ENSP00000381937	Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.502
BLCAP	RBBP9	ENSP00000397172	ENSP00000336866	Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B	Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family	0.503
C4orf29	BLCAP	ENSP00000381937	ENSP00000397172	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B	0.502
C4orf29	C6orf165	ENSP00000381937	ENSP00000358575	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	0.630
C4orf29	CLCA4	ENSP00000381937	ENSP00000359594	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory	0.440
C4orf29	ESF1	ENSP00000381937	ENSP00000202816	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.564
C4orf29	INTU	ENSP00000381937	ENSP00000334003	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...]	0.503
C4orf29	PLEKHH1	ENSP00000381937	ENSP00000330278	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.559
C4orf29	POLR3GL	ENSP00000381937	ENSP00000358320	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC7 RNA polymerase subunit family	0.503
C4orf29	RBBP9	ENSP00000381937	ENSP00000336866	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1; Belongs to the RBBP9 family	0.622
C4orf29	SDR16C5	ENSP00000381937	ENSP00000307607	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family	0.474
C4orf29	SELO	ENSP00000381937	ENSP00000370288	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	Selenoprotein O; May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein	0.519
C6orf165	C4orf29	ENSP00000358575	ENSP00000381937	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.630
C6orf165	ESF1	ENSP00000358575	ENSP00000202816	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.477
C6orf165	PLEKHH1	ENSP00000358575	ENSP00000330278	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.474
C6orf165	POLR3GL	ENSP00000358575	ENSP00000358320	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC7 RNA polymerase subunit family	0.435
C6orf165	SDR16C5	ENSP00000358575	ENSP00000307607	Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes	Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family	0.426
CLCA4	C4orf29	ENSP00000359594	ENSP00000381937	Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory	Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily	0.440
CLCA4	ESF1	ENSP00000359594	ENSP00000202816	Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory	ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)	0.498
CLCA4	INTU	ENSP00000359594	ENSP00000334003	Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory	Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity ef [...]	0.479

page 1 of 3

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About