node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CETN1 | CETN2 | ENSP00000319052 | ENSP00000359300 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | 0.672 |
CETN1 | CETN3 | ENSP00000319052 | ENSP00000428259 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | Centrin-3; EF-hand domain containing | 0.571 |
CETN1 | PCID2 | ENSP00000319052 | ENSP00000479494 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | PCI domain containing 2; Transcription and export complex 2 | 0.569 |
CETN1 | SAC3D1 | ENSP00000319052 | ENSP00000381824 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | 0.786 |
CETN2 | CETN1 | ENSP00000359300 | ENSP00000319052 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.672 |
CETN2 | PCID2 | ENSP00000359300 | ENSP00000479494 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | PCI domain containing 2; Transcription and export complex 2 | 0.686 |
CETN2 | SAC3D1 | ENSP00000359300 | ENSP00000381824 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | 0.786 |
CETN3 | CETN1 | ENSP00000428259 | ENSP00000319052 | Centrin-3; EF-hand domain containing | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.571 |
CETN3 | PCID2 | ENSP00000428259 | ENSP00000479494 | Centrin-3; EF-hand domain containing | PCI domain containing 2; Transcription and export complex 2 | 0.726 |
CETN3 | SAC3D1 | ENSP00000428259 | ENSP00000381824 | Centrin-3; EF-hand domain containing | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | 0.815 |
CETN3 | THOC2 | ENSP00000428259 | ENSP00000245838 | Centrin-3; EF-hand domain containing | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.763 |
PCID2 | CETN1 | ENSP00000479494 | ENSP00000319052 | PCI domain containing 2; Transcription and export complex 2 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.569 |
PCID2 | CETN2 | ENSP00000479494 | ENSP00000359300 | PCI domain containing 2; Transcription and export complex 2 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | 0.686 |
PCID2 | CETN3 | ENSP00000479494 | ENSP00000428259 | PCI domain containing 2; Transcription and export complex 2 | Centrin-3; EF-hand domain containing | 0.726 |
PCID2 | SAC3D1 | ENSP00000479494 | ENSP00000381824 | PCI domain containing 2; Transcription and export complex 2 | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | 0.861 |
PCID2 | THOC2 | ENSP00000479494 | ENSP00000245838 | PCI domain containing 2; Transcription and export complex 2 | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.512 |
PCID2 | TTC4 | ENSP00000479494 | ENSP00000360329 | PCI domain containing 2; Transcription and export complex 2 | Tetratricopeptide repeat domain containing; Belongs to the TTC4 family | 0.836 |
PCID2 | VPS35 | ENSP00000479494 | ENSP00000299138 | PCI domain containing 2; Transcription and export complex 2 | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.862 |
SAC3D1 | CETN1 | ENSP00000381824 | ENSP00000319052 | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing | 0.786 |
SAC3D1 | CETN2 | ENSP00000381824 | ENSP00000359300 | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110; Belongs to the centrin family | 0.786 |