| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C6orf57 | SLC25A45 | ENSP00000359505 | ENSP00000381782 | Succinate dehydrogenase assembly factor 4, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron [...] | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.529 |
| FAM174A | FRMD8 | ENSP00000307954 | ENSP00000319726 | Membrane protein FAM174A; Family with sequence similarity 174 member A | FERM domain containing 8 | 0.795 |
| FAM174A | KDM2A | ENSP00000307954 | ENSP00000432786 | Membrane protein FAM174A; Family with sequence similarity 174 member A | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the [...] | 0.536 |
| FAM174A | LTBP3 | ENSP00000307954 | ENSP00000301873 | Membrane protein FAM174A; Family with sequence similarity 174 member A | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family | 0.484 |
| FAM174A | SLC25A45 | ENSP00000307954 | ENSP00000381782 | Membrane protein FAM174A; Family with sequence similarity 174 member A | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.759 |
| FAM89B | FRMD8 | ENSP00000431459 | ENSP00000319726 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | FERM domain containing 8 | 0.815 |
| FAM89B | LTBP3 | ENSP00000431459 | ENSP00000301873 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family | 0.556 |
| FAM89B | SLC25A45 | ENSP00000431459 | ENSP00000381782 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.527 |
| FAM89B | TIGD3 | ENSP00000431459 | ENSP00000308354 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.702 |
| FRMD8 | FAM174A | ENSP00000319726 | ENSP00000307954 | FERM domain containing 8 | Membrane protein FAM174A; Family with sequence similarity 174 member A | 0.795 |
| FRMD8 | FAM89B | ENSP00000319726 | ENSP00000431459 | FERM domain containing 8 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.815 |
| FRMD8 | KDM2A | ENSP00000319726 | ENSP00000432786 | FERM domain containing 8 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the [...] | 0.536 |
| FRMD8 | LTBP3 | ENSP00000319726 | ENSP00000301873 | FERM domain containing 8 | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family | 0.723 |
| FRMD8 | SLC25A45 | ENSP00000319726 | ENSP00000381782 | FERM domain containing 8 | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.791 |
| FRMD8 | TIGD3 | ENSP00000319726 | ENSP00000308354 | FERM domain containing 8 | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes | 0.743 |
| KDM2A | FAM174A | ENSP00000432786 | ENSP00000307954 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the [...] | Membrane protein FAM174A; Family with sequence similarity 174 member A | 0.536 |
| KDM2A | FRMD8 | ENSP00000432786 | ENSP00000319726 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the [...] | FERM domain containing 8 | 0.536 |
| KDM2A | SLC25A45 | ENSP00000432786 | ENSP00000381782 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the [...] | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family | 0.536 |
| LTBP3 | FAM174A | ENSP00000301873 | ENSP00000307954 | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family | Membrane protein FAM174A; Family with sequence similarity 174 member A | 0.484 |
| LTBP3 | FAM89B | ENSP00000301873 | ENSP00000431459 | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation; Belongs to the FAM89 family | 0.556 |
