• Version:
  • 11.0 [archived version]
STRINGSTRING
PSMA6 PSMA6 RNF170 RNF170 C9orf66 C9orf66 ERICH1 ERICH1 ZNF596 ZNF596 TRIM28 TRIM28 ARHGEF10 ARHGEF10 FBXO25 FBXO25 TDRP TDRP GDPD4 GDPD4 TIGD6 TIGD6
"ZNF596" - Zinc finger protein 596 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF596Zinc finger protein 596; May be involved in transcriptional regulation; Zinc fingers C2H2-type (504 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
TDRP
Testis development related protein (198 aa)
           
  0.703
ERICH1
Glutamate-rich protein 1; Glutamate rich 1 (443 aa)
           
  0.670
FBXO25
F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity); F-boxes other (367 aa)
     
   
  0.668
C9orf66
Uncharacterized protein C9orf66; Chromosome 9 open reading frame 66 (295 aa)
           
  0.528
PSMA6
Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (246 aa)
       
      0.493
TIGD6
Tigger transposable element-derived protein 6; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes (521 aa)
       
 
  0.477
RNF170
E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells; Ring finger proteins (258 aa)
       
 
  0.445
ARHGEF10
Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors (1344 aa)
           
  0.441
GDPD4
Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family (520 aa)
           
  0.441
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]