node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AIFM3 | FAM131C | ENSP00000382120 | ENSP00000364814 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Protein FAM131C; Family with sequence similarity 131 member C | 0.670 |
AIFM3 | FBXL7 | ENSP00000382120 | ENSP00000423630 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins | 0.452 |
AIFM3 | STK32A | ENSP00000382120 | ENSP00000381535 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | Serine/threonine kinase 32A | 0.621 |
ARHGAP25 | STK32A | ENSP00000386911 | ENSP00000381535 | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; Pleckstrin homology domain containing | Serine/threonine kinase 32A | 0.671 |
CHADL | STK32A | ENSP00000216241 | ENSP00000381535 | Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte’s differentiation by acting on its cellular collagenous microenvironment; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily | Serine/threonine kinase 32A | 0.728 |
DPYSL3 | STK32A | ENSP00000343690 | ENSP00000381535 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity) | Serine/threonine kinase 32A | 0.599 |
EVC2 | STK32A | ENSP00000342144 | ENSP00000381535 | Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis | Serine/threonine kinase 32A | 0.599 |
FAM131C | AIFM3 | ENSP00000364814 | ENSP00000382120 | Protein FAM131C; Family with sequence similarity 131 member C | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.670 |
FAM131C | FBXL7 | ENSP00000364814 | ENSP00000423630 | Protein FAM131C; Family with sequence similarity 131 member C | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins | 0.653 |
FAM131C | STK32A | ENSP00000364814 | ENSP00000381535 | Protein FAM131C; Family with sequence similarity 131 member C | Serine/threonine kinase 32A | 0.813 |
FAM84A | STK32A | ENSP00000295092 | ENSP00000381535 | Protein FAM84A; Family with sequence similarity 84 member A | Serine/threonine kinase 32A | 0.594 |
FBXL7 | AIFM3 | ENSP00000423630 | ENSP00000382120 | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.452 |
FBXL7 | FAM131C | ENSP00000423630 | ENSP00000364814 | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins | Protein FAM131C; Family with sequence similarity 131 member C | 0.653 |
FBXL7 | STK32A | ENSP00000423630 | ENSP00000381535 | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins | Serine/threonine kinase 32A | 0.634 |
JAKMIP2 | PPP2R2B | ENSP00000479248 | ENSP00000377936 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity) | 0.497 |
JAKMIP2 | STK32A | ENSP00000479248 | ENSP00000381535 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | Serine/threonine kinase 32A | 0.787 |
PPP2R2B | JAKMIP2 | ENSP00000377936 | ENSP00000479248 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity) | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family | 0.497 |
PPP2R2B | STK32A | ENSP00000377936 | ENSP00000381535 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity) | Serine/threonine kinase 32A | 0.615 |
STK32A | AIFM3 | ENSP00000381535 | ENSP00000382120 | Serine/threonine kinase 32A | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential | 0.621 |
STK32A | ARHGAP25 | ENSP00000381535 | ENSP00000386911 | Serine/threonine kinase 32A | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; Pleckstrin homology domain containing | 0.671 |