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  • 11.0 [archived version]
STRINGSTRING
NOTUM NOTUM EBP EBP COQ5 COQ5 HIGD1C HIGD1C METTL15 METTL15 COX6A2 COX6A2 COX5B COX5B METTL2B METTL2B COX6A1 COX6A1 MT-CO3 MT-CO3 ENSG00000111780 ENSG00000111780
"HIGD1C" - HIG1 hypoxia inducible domain family member 1C in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
HIGD1CHIG1 hypoxia inducible domain family member 1C (97 aa)    
Predicted Functional Partners:
COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2); Seven-beta-strand methyltransferase motif containing (327 aa)
      
   
  0.745
COX5B
Cytochrome c oxidase subunit 5B, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (129 aa)
      
 
  0.509
METTL2B
Methyltransferase-like protein 2B; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs (378 aa)
            
  0.491
ENSG00000111780
Uncharacterized protein; Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (168 aa)
      
 
  0.459
COX6A2
Cytochrome c oxidase subunit 6A2, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (97 aa)
      
 
  0.459
COX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (109 aa)
      
 
  0.459
NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (496 aa)
            
  0.457
MT-CO3
Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex; Mitochondrial complex IV- cytochrome c oxidase subunits (261 aa)
        
 
  0.447
EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family (230 aa)
            
  0.447
METTL15
Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase (407 aa)
            
  0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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