| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANPEP | DPEP1 | ENSP00000300060 | ENSP00000376807 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity | 0.443 |
| ANPEP | GCLC | ENSP00000300060 | ENSP00000229416 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Glutamate-cysteine ligase catalytic subunit | 0.938 |
| ANPEP | GCLM | ENSP00000300060 | ENSP00000359258 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | 0.906 |
| ANPEP | GGT5 | ENSP00000300060 | ENSP00000381340 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.944 |
| ANPEP | GSS | ENSP00000300060 | ENSP00000216951 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family | 0.903 |
| ANPEP | LAP3 | ENSP00000300060 | ENSP00000226299 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; Belongs to the peptidase M17 family | 0.939 |
| DPEP1 | ANPEP | ENSP00000376807 | ENSP00000300060 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | 0.443 |
| DPEP1 | GGT5 | ENSP00000376807 | ENSP00000381340 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.925 |
| DPEP2 | GGT5 | ENSP00000458977 | ENSP00000381340 | Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.945 |
| GCLC | ANPEP | ENSP00000229416 | ENSP00000300060 | Glutamate-cysteine ligase catalytic subunit | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | 0.938 |
| GCLC | GCLM | ENSP00000229416 | ENSP00000359258 | Glutamate-cysteine ligase catalytic subunit | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | 0.999 |
| GCLC | GGT5 | ENSP00000229416 | ENSP00000381340 | Glutamate-cysteine ligase catalytic subunit | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.928 |
| GCLC | GSR | ENSP00000229416 | ENSP00000221130 | Glutamate-cysteine ligase catalytic subunit | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol | 0.899 |
| GCLC | GSS | ENSP00000229416 | ENSP00000216951 | Glutamate-cysteine ligase catalytic subunit | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family | 0.986 |
| GCLC | LAP3 | ENSP00000229416 | ENSP00000226299 | Glutamate-cysteine ligase catalytic subunit | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; Belongs to the peptidase M17 family | 0.902 |
| GCLC | OPLAH | ENSP00000229416 | ENSP00000480476 | Glutamate-cysteine ligase catalytic subunit | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate | 0.910 |
| GCLM | ANPEP | ENSP00000359258 | ENSP00000300060 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization; Aminopeptidases | 0.906 |
| GCLM | GCLC | ENSP00000359258 | ENSP00000229416 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutamate-cysteine ligase catalytic subunit | 0.999 |
| GCLM | GGT5 | ENSP00000359258 | ENSP00000381340 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Belongs to the gamma-glutamyltransferase family | 0.918 |
| GCLM | GSR | ENSP00000359258 | ENSP00000221130 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol | 0.758 |
