CRYBB2 protein (human) - STRING database

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CRYBB2

Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family (205 aa)

Predicted Functional Partners:

HSPB4

0.956

CRYA1

0.934

GJA3

0.921

CRYAB

0.903

CRYBB3

0.816

GJA8

0.814

BFSP2

0.812

HSF4

0.810

MIP

0.767

TMEM114

0.744

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFSP2	CRYA1	ENSP00000304987	ENSP00000482816	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	CRYAB	ENSP00000304987	ENSP00000433560	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.708
BFSP2	CRYBB2	ENSP00000304987	ENSP00000381273	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.812
BFSP2	CRYBB3	ENSP00000304987	ENSP00000215855	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.719
BFSP2	GJA3	ENSP00000304987	ENSP00000241125	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.835
BFSP2	GJA8	ENSP00000304987	ENSP00000358238	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.762
BFSP2	HSF4	ENSP00000304987	ENSP00000264009	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	0.840
BFSP2	HSPB4	ENSP00000304987	ENSP00000291554	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.819
BFSP2	MIP	ENSP00000304987	ENSP00000257979	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.814
BFSP2	TMEM114	ENSP00000304987	ENSP00000484263	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	Transmembrane protein 114	0.698
CRYA1	BFSP2	ENSP00000482816	ENSP00000304987	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.819
CRYA1	CRYAB	ENSP00000482816	ENSP00000433560	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.913
CRYA1	CRYBB2	ENSP00000482816	ENSP00000381273	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.934
CRYA1	CRYBB3	ENSP00000482816	ENSP00000215855	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.876
CRYA1	GJA3	ENSP00000482816	ENSP00000241125	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.850
CRYA1	GJA8	ENSP00000482816	ENSP00000358238	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell	0.835
CRYA1	HSF4	ENSP00000482816	ENSP00000264009	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription	0.795
CRYA1	MIP	ENSP00000482816	ENSP00000257979	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling; Belongs to the MIP/aquaporin (TC 1.A.8) family	0.716
CRYA1	TMEM114	ENSP00000482816	ENSP00000484263	Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Transmembrane protein 114	0.698
CRYAB	BFSP2	ENSP00000433560	ENSP00000304987	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family	0.708

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