| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASPM | EFCAB9 | ENSP00000356379 | ENSP00000381247 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.461 |
| EFCAB9 | ASPM | ENSP00000381247 | ENSP00000356379 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex [...] | 0.461 |
| EFCAB9 | IQCG | ENSP00000381247 | ENSP00000265239 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility | 0.401 |
| EFCAB9 | MYH10 | ENSP00000381247 | ENSP00000353590 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | 0.634 |
| EFCAB9 | OBSCN | ENSP00000381247 | ENSP00000455507 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | 0.601 |
| EFCAB9 | PPP3CA | ENSP00000381247 | ENSP00000378323 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.406 |
| EFCAB9 | PPP3CB | ENSP00000381247 | ENSP00000378306 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | 0.406 |
| EFCAB9 | PPP3CC | ENSP00000381247 | ENSP00000380878 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.406 |
| EFCAB9 | SPEG | ENSP00000381247 | ENSP00000311684 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing | 0.601 |
| IQCG | EFCAB9 | ENSP00000265239 | ENSP00000381247 | IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (Probable). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.401 |
| MYH10 | EFCAB9 | ENSP00000353590 | ENSP00000381247 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.634 |
| OBSCN | EFCAB9 | ENSP00000455507 | ENSP00000381247 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.601 |
| PPP3CA | EFCAB9 | ENSP00000378323 | ENSP00000381247 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.406 |
| PPP3CA | PPP3CB | ENSP00000378323 | ENSP00000378306 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | 0.904 |
| PPP3CA | PPP3CC | ENSP00000378323 | ENSP00000380878 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.904 |
| PPP3CB | EFCAB9 | ENSP00000378306 | ENSP00000381247 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.406 |
| PPP3CB | PPP3CA | ENSP00000378306 | ENSP00000378323 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.904 |
| PPP3CB | PPP3CC | ENSP00000378306 | ENSP00000380878 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.982 |
| PPP3CC | EFCAB9 | ENSP00000380878 | ENSP00000381247 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 | 0.406 |
| PPP3CC | PPP3CA | ENSP00000380878 | ENSP00000378323 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.904 |
